CAJ | 학술논문

端粒作为染色体的保护结构，在维持染色体稳定和结构完整上起着重要作用。而端粒酶具有过延长端粒的功能，是维持端粒长度的重要酶复合体。端粒酶延长端粒的过程是一个涉及多种因子多个环节的复杂过程。主要涉及端粒自身结构相关调节以及端粒酶相关的调节。端粒酶相关调节是调节系统中最重要的组成部分。包括TR自身结构的影响，调节因子对TERT启动子的调节等。
단립작위염색체적보호결구，재유지염색체은정화결구완정상기착중요작용。이단립매구유과연장단립적공능，시유지단립장도적중요매복합체。단립매연장단립적과정시일개섭급다충인자다개배절적복잡과정。주요섭급단립자신결구상관조절이급단립매상관적조절。단립매상관조절시조절계통중최중요적조성부분。포괄TR자신결구적영향，조절인자대TERT계동자적조절등。
As the protection of the chromosome structure, telomere plays an important role in maintaining the stability and structural in-tegrity of chromosomes.The telomerase is one of the important enzymes maintaining telomere length, and telomere elongated process is a complicated process involving a variety of factors, mainly related to telomere structure and telomerase regulation.The telomerase related regulation is the most important part of the control system, including the influence of TR structure, regulation on TERT promoter etc.