CAJ | 학술논문

目的探讨原发性乳腺鳞状细胞癌的临床病理特征及预后.方法对天津医科大学肿瘤医院1984-2013年收治的23例原发性乳腺鳞状细胞癌患者临床及病理资料进行回顾性分析.结果原发性乳腺鳞状细胞癌发病率低,约占同期乳腺癌患者的0.06％.患者全部为女性,发病年龄28 ～87岁,中位年龄49岁;肿瘤平均大小为4.5 cm.9例患者就诊时伴有淋巴结转移(39.1％).雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、人表皮生长因子受体(human epithelial growth factor receptor 2,HER-2)阳性率分别为13.0％(3/23)、4.3％ (1/23)、0(0/20).8例患者在随访5～36个月后出现复发或转移,1例患者入院时伴远处转移.9例出现复发或转移的患者中,肺转移较为常见(77.7％),6例死亡.结论原发性乳腺鳞状细胞癌是一种少见的化生性癌,侵袭性强、受体阴性率高,且治疗后早期容易出现复发或转移,预后差.
목적 탐토원발성유선린상세포암적림상병리특정급예후.방법 대천진의과대학종류의원1984-2013년수치적23례원발성유선린상세포암환자림상급병리자료진행회고성분석.결과원발성유선린상세포암발병솔저,약점동기유선암환자적0.06％.환자전부위녀성,발병년령28 ～87세,중위년령49세;종류평균대소위4.5 cm.9례환자취진시반유림파결전이(39.1％).자격소수체(estrogen receptor,ER)、잉격소수체(progesterone receptor,PR)、인표피생장인자수체(human epithelial growth factor receptor 2,HER-2)양성솔분별위13.0％(3/23)、4.3％ (1/23)、0(0/20).8례환자재수방5～36개월후출현복발혹전이,1례환자입원시반원처전이.9례출현복발혹전이적환자중,폐전이교위상견(77.7％),6례사망.결론 원발성유선린상세포암시일충소견적화생성암,침습성강、수체음성솔고,차치료후조기용역출현복발혹전이,예후차.
Objective To investigate the clinical and pathologic features of squamous cell carcinoma of the breast.Methods The clinical and pathologic data of 23 squamous cell carcinoma of the breast patients admitted between 1984 and 2013 to Tianjin Medical University Cancer Hospital was analyzed retrospectively.Results Primary squamous cell carcinoma of the breast was a very rare tumor accounting for 0.06％ of all breast cancers.All of the 23 patients were females aged 28 years to 87 years(median age 49 years).Average tumor size was 4.5 cm.9 patients suffered from lymph node metastasis at admission (39.1％).The positive rates of estrogen receptor (ER),progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) were 13.6％ (3/23),4.5％ (1/23) and 0 (0/20) respectively.With a follow-up time varying from 5 months to 36 months recurrence or metastasis were found in 8 patients,and another 1 patient was found having distant metastasis at admission.Lung metastasis (7/9) was most common.6 patients died.Conclusions Squamous cell carcinoma of the breast is highly invasive,with low rate of positive receptors and early distant metastasis or recurrence after operation,and poor patients' survival.