CAJ | 학술논문

以吗啡啉，1，4-二溴丁烷和无水碳酸钾为原料，以水为溶剂，通过季铵化反应合成出溴代8-氧杂-螺[4，5]季铵盐．研究了原料比、反应温度、回流时间对吗啡啉转化率的影响，结果表明，吗啡啉、1，4-二溴丁烷、无水碳酸钾的用量分别为0.10 mol，0.14 mol 和0.11 mol，回流3 h，反应温度为110℃时，吗啡啉转化率达91.7％．最终采用核磁共振、红外光谱、热重分析和液相色谱-质谱联用对产物的结构进行了表征．
이마배람，1，4-이추정완화무수탄산갑위원료，이수위용제，통과계안화반응합성출추대8-양잡-라[4，5]계안염．연구료원료비、반응온도、회류시간대마배람전화솔적영향，결과표명，마배람、1，4-이추정완、무수탄산갑적용량분별위0.10 mol，0.14 mol 화0.11 mol，회류3 h，반응온도위110℃시，마배람전화솔체91.7％．최종채용핵자공진、홍외광보、열중분석화액상색보-질보련용대산물적결구진행료표정．
Branched 8-oxa-spiro [4,5]quaternary ammonium salt was synthesized by using morpholino,1 ,4-dibromo-butane and anhydrous potassium carbonate as raw materials and using water as solvent through quatern-ization reaction.The effect of material ratio,temperature and reaction time on the conversion rate of morpholino were studied.The results show that:the amount of morpholino,1 ,4-dibromo-butane,potassium carbonate are 0.10 mol,0.14 mol,0.11 mol,refluxed for 3 hours and the temperature is 110 ℃,the conversion rate of mor-pholine was 91.7%.Finally the research characterized the structure of product through HNMR,IR,TG and HPLC-MS.