CAJ | 학술논문

目的：探讨miR‐155在肾透明细胞癌（clear renal cell carcinoma ，CCRCC ）中的表达及意义。方法采用实时定量PCR技术检测18例CCRCC患者新鲜肿瘤组织及癌旁非肿瘤组织中miR‐155的表达情况。结果与配对的癌旁非肿瘤组织相比，肿瘤组织中miR‐155的表达在16例（88.9％）的样本中上调，在2例样本中表达下调，其中CCRCC中miR‐155的相对表达量为2.08～26.05，平均（12.70±6.52），癌旁非肿瘤组织中相对表达量为1.00～6.79，平均为（2.82±1.25），改变有显著统计学差异（ P＜0.05）。根据病理分级样分组，高分化组 miR‐155的相对含量为（11.43±6.18），中‐低分化组为（14.33±7.04），结果有显著统计学差异（P＜0.05）。结论 miR‐155表达上调可能与CCRCC的发病机制相关，其表达水平与Fuhr‐man病理分级密切相关。
목적：탐토miR‐155재신투명세포암（clear renal cell carcinoma ，CCRCC ）중적표체급의의。방법채용실시정량PCR기술검측18례CCRCC환자신선종류조직급암방비종류조직중miR‐155적표체정황。결과여배대적암방비종류조직상비，종류조직중miR‐155적표체재16례（88.9％）적양본중상조，재2례양본중표체하조，기중CCRCC중miR‐155적상대표체량위2.08～26.05，평균（12.70±6.52），암방비종류조직중상대표체량위1.00～6.79，평균위（2.82±1.25），개변유현저통계학차이（ P＜0.05）。근거병리분급양분조，고분화조 miR‐155적상대함량위（11.43±6.18），중‐저분화조위（14.33±7.04），결과유현저통계학차이（P＜0.05）。결론 miR‐155표체상조가능여CCRCC적발병궤제상관，기표체수평여Fuhr‐man병리분급밀절상관。
Objective To explore the functional role and mechanism of miR‐155 in the development of clear cell renal cell car‐cinoma (CCRCC) .Methods MiR‐155 expression was quantified in renal cancers and matched adjacent non tumor tissues using quantitative real‐time PCR (RT‐PCR) .Results MiR‐155 expressions were up‐regulated in 16 renal cancer tissues (88.9% ) and down‐regulated in 2 renal cancer tissues .Expression level of miR‐155 in renal cancer tissues was significantly higher than that in adjacent normal tissues (12.70 ± 6.52 vs 2.82 ± 1.25 ,P<0.05) and higher expression of miR‐155 was observed in cases with higher stages (11.43 ± 6.18 vs 14.33 ± 7.04 ,P<0.05) .Conclusion Upregulation of miR‐155 may be associated with the path‐ogenesis of CCRCC ,and the expression level is closely related with the Fuhrman pathological grading .