中华关节外科杂志(电子版)
中華關節外科雜誌(電子版)
중화관절외과잡지(전자판)
Chinese Journal of Joint Surgery (Electronic Version)
2015年
5期
676-679
,共4页
于利%李长洲%王腾飞%汤欣
于利%李長洲%王騰飛%湯訢
우리%리장주%왕등비%탕흔
唑来膦酸%骨质疏松%骨折%骨密度
唑來膦痠%骨質疏鬆%骨摺%骨密度
서래련산%골질소송%골절%골밀도
Zoledronicacid%Osteoporosis%Fractures,bone%Bonedensity
目的:评价骨质疏松骨折术后应用唑来膦酸的临床疗效。方法选取2012年1月至2014年2月本组收治的骨质疏松骨折患者30例,其中女24例,男6例;年龄53~80岁,平均(67.6±8.1)岁。所有患者均予手术治疗,术后给予唑来膦酸注射液5 mg静脉滴注,其中术后5~7 d应用5例,术后1个月25例。术后12、24、36个月复查并记录骨密度变化,同时观察骨折愈合情况,记录治疗期间的症状和不良发应。结果本组患者治疗1年后骨密度均有所提高,且差异有统计学意义(P<0.05),连续应用3年骨密度持续提高,差异有统计学意义(P<0.05)。首次给予唑来膦酸治疗后,均出现不同程度的发热、乏力、头痛、关节痛、恶心等反应,再次应用不良反应明显减少( P<0.05)。无骨折不愈合、骨不连、术后内固定松动、断裂,螺钉退出等并发症发生。无再骨折发生。结论骨质疏松骨折术后应用唑来膦酸可以有效降低再骨折率、提高骨密度,且并不影响骨折愈合。
目的:評價骨質疏鬆骨摺術後應用唑來膦痠的臨床療效。方法選取2012年1月至2014年2月本組收治的骨質疏鬆骨摺患者30例,其中女24例,男6例;年齡53~80歲,平均(67.6±8.1)歲。所有患者均予手術治療,術後給予唑來膦痠註射液5 mg靜脈滴註,其中術後5~7 d應用5例,術後1箇月25例。術後12、24、36箇月複查併記錄骨密度變化,同時觀察骨摺愈閤情況,記錄治療期間的癥狀和不良髮應。結果本組患者治療1年後骨密度均有所提高,且差異有統計學意義(P<0.05),連續應用3年骨密度持續提高,差異有統計學意義(P<0.05)。首次給予唑來膦痠治療後,均齣現不同程度的髮熱、乏力、頭痛、關節痛、噁心等反應,再次應用不良反應明顯減少( P<0.05)。無骨摺不愈閤、骨不連、術後內固定鬆動、斷裂,螺釘退齣等併髮癥髮生。無再骨摺髮生。結論骨質疏鬆骨摺術後應用唑來膦痠可以有效降低再骨摺率、提高骨密度,且併不影響骨摺愈閤。
목적:평개골질소송골절술후응용서래련산적림상료효。방법선취2012년1월지2014년2월본조수치적골질소송골절환자30례,기중녀24례,남6례;년령53~80세,평균(67.6±8.1)세。소유환자균여수술치료,술후급여서래련산주사액5 mg정맥적주,기중술후5~7 d응용5례,술후1개월25례。술후12、24、36개월복사병기록골밀도변화,동시관찰골절유합정황,기록치료기간적증상화불량발응。결과본조환자치료1년후골밀도균유소제고,차차이유통계학의의(P<0.05),련속응용3년골밀도지속제고,차이유통계학의의(P<0.05)。수차급여서래련산치료후,균출현불동정도적발열、핍력、두통、관절통、악심등반응,재차응용불량반응명현감소( P<0.05)。무골절불유합、골불련、술후내고정송동、단렬,라정퇴출등병발증발생。무재골절발생。결론골질소송골절술후응용서래련산가이유효강저재골절솔、제고골밀도,차병불영향골절유합。
Objective To evaluate the efficacy of zoledronic acid in patients after osteoporotic fracture operation.Methods A total of 30 patients with osteoporotic fracture hospitalized from Jan.2012 to Feb.2014 were enrolled in this study, including 24 females and 6 males, aged from 53 to 80 years (67.6 ±8.1 on average).All the patients were given 5 mg zoledronic acid injection through intravenous drip after the operation; five patients were treated for 5 -7 days and 25 patients were treated for one month.The changes of the bone mineral density ( BMD) were reviewed and recorded respectively at 12 months, 24 months and 36 months after the operation.Fracture healing, symptoms and adverse reactions were recorded during the treatment.Results After one-year treatment, the BMD of the patients increased and the difference was statistically significant (P<0.05).The BMD continuously improved when the drug was continually given for three years and the difference was statistically significant ( P<0.05 ) .All the patients developed different extent of adverse reaction, including fever, fatigue, headache, joint pain and nausea after the first infusion of zoledronic acid.The adverse reactions significantly reduced since the second infusion ( P<0.05) .No complication was observed such as fracture, bone nonunion, postoperative internal fixation loosening and rupture, or screw exiting; no new osteoporotic fracture was observed. Conclusion The application of zoledronic acid after osteoporotic fracture operation can effectively reduce new osteoporotic fracture rate, increase BMD, and does not affect the fracture healing.