CAJ | 학술논문

胃癌是消化系统常见的恶性肿瘤，发病率和死亡率分别占全球肿瘤的第4位和第2位。胃癌的发生由遗传、环境等诸多因素相互作用所致，是一个多因素、多步骤参与的癌变过程。热休克蛋白（HSP）70是 HSP 家族中最重要的一类具有分子伴侣作用的蛋白，参与机体特异性免疫和固有免疫。研究表明 HSP70与胃癌的发生、发展密切相关。本文就 HSP70与胃癌相关性的研究进展作一综述。
위암시소화계통상견적악성종류，발병솔화사망솔분별점전구종류적제4위화제2위。위암적발생유유전、배경등제다인소상호작용소치，시일개다인소、다보취삼여적암변과정。열휴극단백（HSP）70시 HSP 가족중최중요적일류구유분자반려작용적단백，삼여궤체특이성면역화고유면역。연구표명 HSP70여위암적발생、발전밀절상관。본문취 HSP70여위암상관성적연구진전작일종술。
Gastric cancer is one of the most commonly seen malignant tumors,and is the fourth leading cause of morbidity and second leading cause of mortality among malignancies worldwide. The genesis of gastric cancer is the result of interaction between genetic and environmental factors,and is a multi-factor and multi-step carcinogenesis. As one of the most important members in the heat shock protein(HSP)family,HSP70 plays a molecular chaperone role,and is involved in body specific immunity and innate immunity. Studies have demonstrated that over expression of HSP70 often correlates with the genesis and development of gastric cancer. This article reviewed the advances in study on relationship between HSP70 and gastric cancer.