胃肠病学
胃腸病學
위장병학
Chinese Journal of Gastroenterology
2015年
9期
563-566
,共4页
肝纤维化%肝星状细胞%微 RNAs%上皮-间质转化
肝纖維化%肝星狀細胞%微 RNAs%上皮-間質轉化
간섬유화%간성상세포%미 RNAs%상피-간질전화
Liver Fibrosis%Hepatic Stellate Cells%MicroRNAs%Epithelial-Mesenchymal Transition
肝纤维化是对多种损害因素引起的慢性肝损伤所进行的修复反应。肝星状细胞（HSC）激活、增殖是肝纤维化发生、发展的关键环节。近年研究发现，微小 RNA（miRNA）参与调控 HSC 激活、增殖等相关信号通路。本文就 miRNA 调控 HSC 生物学行为在肝纤维化中的作用作一综述。
肝纖維化是對多種損害因素引起的慢性肝損傷所進行的脩複反應。肝星狀細胞（HSC）激活、增殖是肝纖維化髮生、髮展的關鍵環節。近年研究髮現，微小 RNA（miRNA）參與調控 HSC 激活、增殖等相關信號通路。本文就 miRNA 調控 HSC 生物學行為在肝纖維化中的作用作一綜述。
간섬유화시대다충손해인소인기적만성간손상소진행적수복반응。간성상세포（HSC）격활、증식시간섬유화발생、발전적관건배절。근년연구발현，미소 RNA（miRNA）삼여조공 HSC 격활、증식등상관신호통로。본문취 miRNA 조공 HSC 생물학행위재간섬유화중적작용작일종술。
Liver fibrosis is a repair response to chronic liver injury caused by liver metabolic disorders due to many injury factors. Hepatic stellate cell(HSC)activation and proliferation play an important role in the pathogenesis of liver fibrosis. In recent years,studies showed that microRNAs(miRNA)are involved in signal transduction pathways related with HSC activation and proliferation. This article reviewed the role of miRNA in regulation of HSC biological behavior in liver fibrogenesis.
