以核素标记前列腺特异性膜抗原小分子抑制剂为探针的前列腺癌分子影像研究进展
이핵소표기전렬선특이성막항원소분자억제제위탐침적전렬선암분자영상연구진전
Advances in molecular imaging of prostate cancer targeting prostate specific membrane antigen with small molecular radionuclide probes
  • 万方数据
    肿瘤影像学 종류영상학
    Oncoradiology
    2015年 3期 161-167 ,共7页

    胡四龙(综述)%许晓平%章英剑(审校)

    호사룡(종술)%허효평%장영검(심교)

    前列腺癌%前列腺特异性膜抗原%分子影像%放射性核素显像 前列腺癌%前列腺特異性膜抗原%分子影像%放射性覈素顯像
    전렬선암%전렬선특이성막항원%분자영상%방사성핵소현상
    Prostate carcinoma%Prostate-speciifc membrane antigen%Molecular imaging%Radionuclide imaging
    前列腺特异性膜抗原(PSMA)高表达于前列腺癌及其转移灶中，可作为生物分子靶点，在前列腺癌的早期诊断、分期、复发检测、预后判断及靶向治疗中具有重要价值。本文重点综述以核素标记PSMA小分子抑制剂为探针的前列腺癌分子影像研究进展。
    전렬선특이성막항원(PSMA)고표체우전렬선암급기전이조중，가작위생물분자파점，재전렬선암적조기진단、분기、복발검측、예후판단급파향치료중구유중요개치。본문중점종술이핵소표기PSMA소분자억제제위탐침적전렬선암분자영상연구진전。
    Prostate speciifc membrane antigen (PSMA) is expressed in normal prostate epithelial cells and strongly up regulated in initial and advanced prostate carcinoma. Therefore, PSMA is an attractive molecular target for the detection of primary and metastatic lesions. It plays an important role in the diagnosis, staging, prognostic evaluation and targeted treatment in prostate carcinoma patients. This review will summarize the progress of small molecular radionuclide probes, which targeted PSMA, for visualizing prostate cancer.
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