中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
9期
124-126
,共3页
双香豆素%急性脑梗塞%肿瘤坏死因子-α%神经功能
雙香豆素%急性腦梗塞%腫瘤壞死因子-α%神經功能
쌍향두소%급성뇌경새%종류배사인자-α%신경공능
dicoumarol%acute cerebral infarction%tumor necrosis factor-α%neurologic function
目的：探讨双香豆素对急性脑梗塞患者血清中肿瘤坏死因子-α（ tumor necrosis factor-α，TNF-α）的表达影响。方法将泸州医学院附属医院收治的80例急性脑梗塞患者按数字抽签法随机分为2组：对照组和观察组，每组各40例。对照组采用常规急性脑梗塞疗法进行治疗，观察组在对照组基础上采用双香豆素溶栓法进行治疗。观察并分析2组患者在治疗前后血清中TNF-α水平及患者神经功能缺损情况。结果治疗后6 h时，观察组血清TNF-α水平显著低于对照组（ P＜0.05）。但治疗24、48 h及30 d时，2组患者血清TNF-α表达水平差异无统计学意义。在第5、14、28 d时观察组神经功能缺损评分显著高于对照组（P＜0.05）。结论双香豆素可有效降低患者血清中TNF-α水平及患者脑细胞的损伤程度。
目的：探討雙香豆素對急性腦梗塞患者血清中腫瘤壞死因子-α（ tumor necrosis factor-α，TNF-α）的錶達影響。方法將瀘州醫學院附屬醫院收治的80例急性腦梗塞患者按數字抽籤法隨機分為2組：對照組和觀察組，每組各40例。對照組採用常規急性腦梗塞療法進行治療，觀察組在對照組基礎上採用雙香豆素溶栓法進行治療。觀察併分析2組患者在治療前後血清中TNF-α水平及患者神經功能缺損情況。結果治療後6 h時，觀察組血清TNF-α水平顯著低于對照組（ P＜0.05）。但治療24、48 h及30 d時，2組患者血清TNF-α錶達水平差異無統計學意義。在第5、14、28 d時觀察組神經功能缺損評分顯著高于對照組（P＜0.05）。結論雙香豆素可有效降低患者血清中TNF-α水平及患者腦細胞的損傷程度。
목적：탐토쌍향두소대급성뇌경새환자혈청중종류배사인자-α（ tumor necrosis factor-α，TNF-α）적표체영향。방법장로주의학원부속의원수치적80례급성뇌경새환자안수자추첨법수궤분위2조：대조조화관찰조，매조각40례。대조조채용상규급성뇌경새요법진행치료，관찰조재대조조기출상채용쌍향두소용전법진행치료。관찰병분석2조환자재치료전후혈청중TNF-α수평급환자신경공능결손정황。결과치료후6 h시，관찰조혈청TNF-α수평현저저우대조조（ P＜0.05）。단치료24、48 h급30 d시，2조환자혈청TNF-α표체수평차이무통계학의의。재제5、14、28 d시관찰조신경공능결손평분현저고우대조조（P＜0.05）。결론쌍향두소가유효강저환자혈청중TNF-α수평급환자뇌세포적손상정도。
Objective To investigate effect of dicoumarol on the expression of serum tumor necrosis factor-α( TNF-α) in patients with acute cerebral infarction.Methods Eighty cases patients with acute cerebral infarction were admitted and randomly divided into two groups by digital draw:control group and observation group, 40 cases in each group.The control group were given conventional therapy for treatment of acute cerebral infarction, and observation group were given dicoumarol thrombolysis on the basis of control group.The serum TNF-αlevel and neurologic impairment score were compared between two groups pre-and post-treatment.Results After treatment of 6 h, the serum TNF-αlevel in observation group was significantly lower than that in control group (P<0.05).After treatment of 24 h, 48 h and 30 d, there were no significant differences of serum TNF-αlevels between two groups.After treatment of 5 d, 14 d and 28 d, the neurological deficit scores in observation group were significantly higher than those in control group (P<0.05).Conclusion Dicoumarol could effectively reduce TNF-αlevels in serum and extent of cerebral cell damage in patients.
