中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
9期
121-123
,共3页
罗红芳%龙月婷%梁建华%杨希慧
囉紅芳%龍月婷%樑建華%楊希慧
라홍방%룡월정%량건화%양희혜
单磷酸阿糖腺苷%黄芪注射液%心脏肌钙蛋白1%白细胞介素1β%白细胞介素-10%肿瘤坏死因子α
單燐痠阿糖腺苷%黃芪註射液%心髒肌鈣蛋白1%白細胞介素1β%白細胞介素-10%腫瘤壞死因子α
단린산아당선감%황기주사액%심장기개단백1%백세포개소1β%백세포개소-10%종류배사인자α
vidarabine monophosphate%astragalus injection%cardiac troponin I%interleukin 1β%interleukin-10%tumor necrosis factor-α
目的:探讨单磷酸阿糖腺苷联合黄芪注射液对小儿手足口病患者血清心脏肌钙蛋白1(cardiac troponin I,cTnI),白细胞介素1β(interleukin 1β,IL-1β),白细胞介素-10(interleukin-10,IL-10)和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平影响的研究。方法收集2013年3月~2015年3月于贵阳医学院第二附属医院儿科收治的手足口病患儿60例,根据治疗方法不同分为对照组和实验组,每组各30例。对照组给予常规支持治疗+利巴韦林注射液,实验组在常规支持治疗基础上给予单磷酸阿糖腺苷+黄芪注射液,均1次/天。7 d为1个疗程。治疗结束后对所有患者的血清cTnI,IL-1β,IL-10及TNF-α水平进行检测。结果治疗后,2组患者的cTnI、IL-1β、IL-10及TNF-α水平均较治疗前显著降低( P<0.05),实验组患者的上述指标均显著低于对照组( P<0.05)。结论磷酸阿糖腺苷联合黄芪注射液能够显著降低小儿手足口病患者血清cTnⅠ、IL-1β、IL-10和TNF-α水平。
目的:探討單燐痠阿糖腺苷聯閤黃芪註射液對小兒手足口病患者血清心髒肌鈣蛋白1(cardiac troponin I,cTnI),白細胞介素1β(interleukin 1β,IL-1β),白細胞介素-10(interleukin-10,IL-10)和腫瘤壞死因子α(tumor necrosis factor-α,TNF-α)水平影響的研究。方法收集2013年3月~2015年3月于貴暘醫學院第二附屬醫院兒科收治的手足口病患兒60例,根據治療方法不同分為對照組和實驗組,每組各30例。對照組給予常規支持治療+利巴韋林註射液,實驗組在常規支持治療基礎上給予單燐痠阿糖腺苷+黃芪註射液,均1次/天。7 d為1箇療程。治療結束後對所有患者的血清cTnI,IL-1β,IL-10及TNF-α水平進行檢測。結果治療後,2組患者的cTnI、IL-1β、IL-10及TNF-α水平均較治療前顯著降低( P<0.05),實驗組患者的上述指標均顯著低于對照組( P<0.05)。結論燐痠阿糖腺苷聯閤黃芪註射液能夠顯著降低小兒手足口病患者血清cTnⅠ、IL-1β、IL-10和TNF-α水平。
목적:탐토단린산아당선감연합황기주사액대소인수족구병환자혈청심장기개단백1(cardiac troponin I,cTnI),백세포개소1β(interleukin 1β,IL-1β),백세포개소-10(interleukin-10,IL-10)화종류배사인자α(tumor necrosis factor-α,TNF-α)수평영향적연구。방법수집2013년3월~2015년3월우귀양의학원제이부속의원인과수치적수족구병환인60례,근거치료방법불동분위대조조화실험조,매조각30례。대조조급여상규지지치료+리파위림주사액,실험조재상규지지치료기출상급여단린산아당선감+황기주사액,균1차/천。7 d위1개료정。치료결속후대소유환자적혈청cTnI,IL-1β,IL-10급TNF-α수평진행검측。결과치료후,2조환자적cTnI、IL-1β、IL-10급TNF-α수평균교치료전현저강저( P<0.05),실험조환자적상술지표균현저저우대조조( P<0.05)。결론린산아당선감연합황기주사액능구현저강저소인수족구병환자혈청cTnⅠ、IL-1β、IL-10화TNF-α수평。
Objective To explore effect of vidarabine monophosphate combined with astragalus injection on serum cardiac troponin I ( cTnI), interleukin 1β(IL-1β), interleukin-10 (IL-10) and tumor necrosis factor-α(TNF-α) in children with hand-foot-and-mouth disease.Methods 60 cases with hand-foot-and-mouth disease from March 2013 to March 2015 in the hospital were selected and divided into two groups treated by different therapy, 30 cases in each group.The control group received conventional treatment + ribavirin injection, and experimental group received vidarabine monophosphate combined with astragalus injection on the basis of conventional treatment, one time per day.All patients were treated for a course of 7 days.The serum cTnI,IL-1β,IL-10 and TNF-αlevels were compared before and after treatment.Results After treatment, the serum cTnI, IL-1β, IL-10 and TNF-αlevels in two groups decreased than those of pre-treatment (P<0.05), the above indicators of experimental group were lower than those of control group (P<0.05).Conclusion The combination of vidarabine monophosphate and astragalus injection could significantly decrease serum cTnI, IL-1β, IL-10 and TNF-αlevels in children with hand-foot-and-mouth disease.