中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
9期
118-120
,共3页
黄褐斑%复方木尼孜其颗粒%维A酸乳膏%临床疗效%内分泌
黃褐斑%複方木尼孜其顆粒%維A痠乳膏%臨床療效%內分泌
황갈반%복방목니자기과립%유A산유고%림상료효%내분비
chloasma%compound Muniziqi granules%vitamin A acid cream%clinical effect%endocrine
目的：观察复方木尼孜其颗粒联合维A酸乳膏治疗黄褐斑的临床疗效，并分析其作用机制。方法选取2010年3月～2014年2月在海宁市尖山新区卫生院接受治疗的黄褐斑患者76例，按照随机数字表法分为2组，每组38例，观察组给予复方木尼孜其颗粒（3次／天，口服）联合外用0.025％维A酸乳膏（早晚各涂抹1次）治疗，对照组给予维生素C 0.3 g，维生素E 0.2 g（3次／天，口服）联合外用0.025％维A酸乳膏（早晚各1次）治疗。观察2组的临床疗效、皮损面积评分及颜色评分情况，并采用放射免疫法检测2组的血清雌激素水平。结果与治疗前相比，观察组治疗后皮损面积评分、颜色评分显著降低（ P＜0.05）；与对照组治疗后相比，观察组皮损面积评分、颜色评分显著降低（P＜0.05）；观察组临床有效率（94.74％）显著高于对照组临床有效率（75.31％）（P＜0.05）；与治疗前相比，观察组治疗后血清E2、FSH、LH水平均显著降低（ P＜0.05）；与对照组治疗后比较，观察组血清E2、FSH、LH水平显著降低（ P＜0.05）。结论复方木尼孜其颗粒联合维A酸乳膏治疗黄褐斑的疗效显著。其作用机制可能与雌二醇、卵泡刺激素、促黄体生成素等雌激素水平相关。
目的：觀察複方木尼孜其顆粒聯閤維A痠乳膏治療黃褐斑的臨床療效，併分析其作用機製。方法選取2010年3月～2014年2月在海寧市尖山新區衛生院接受治療的黃褐斑患者76例，按照隨機數字錶法分為2組，每組38例，觀察組給予複方木尼孜其顆粒（3次／天，口服）聯閤外用0.025％維A痠乳膏（早晚各塗抹1次）治療，對照組給予維生素C 0.3 g，維生素E 0.2 g（3次／天，口服）聯閤外用0.025％維A痠乳膏（早晚各1次）治療。觀察2組的臨床療效、皮損麵積評分及顏色評分情況，併採用放射免疫法檢測2組的血清雌激素水平。結果與治療前相比，觀察組治療後皮損麵積評分、顏色評分顯著降低（ P＜0.05）；與對照組治療後相比，觀察組皮損麵積評分、顏色評分顯著降低（P＜0.05）；觀察組臨床有效率（94.74％）顯著高于對照組臨床有效率（75.31％）（P＜0.05）；與治療前相比，觀察組治療後血清E2、FSH、LH水平均顯著降低（ P＜0.05）；與對照組治療後比較，觀察組血清E2、FSH、LH水平顯著降低（ P＜0.05）。結論複方木尼孜其顆粒聯閤維A痠乳膏治療黃褐斑的療效顯著。其作用機製可能與雌二醇、卵泡刺激素、促黃體生成素等雌激素水平相關。
목적：관찰복방목니자기과립연합유A산유고치료황갈반적림상료효，병분석기작용궤제。방법선취2010년3월～2014년2월재해저시첨산신구위생원접수치료적황갈반환자76례，안조수궤수자표법분위2조，매조38례，관찰조급여복방목니자기과립（3차／천，구복）연합외용0.025％유A산유고（조만각도말1차）치료，대조조급여유생소C 0.3 g，유생소E 0.2 g（3차／천，구복）연합외용0.025％유A산유고（조만각1차）치료。관찰2조적림상료효、피손면적평분급안색평분정황，병채용방사면역법검측2조적혈청자격소수평。결과여치료전상비，관찰조치료후피손면적평분、안색평분현저강저（ P＜0.05）；여대조조치료후상비，관찰조피손면적평분、안색평분현저강저（P＜0.05）；관찰조림상유효솔（94.74％）현저고우대조조림상유효솔（75.31％）（P＜0.05）；여치료전상비，관찰조치료후혈청E2、FSH、LH수평균현저강저（ P＜0.05）；여대조조치료후비교，관찰조혈청E2、FSH、LH수평현저강저（ P＜0.05）。결론복방목니자기과립연합유A산유고치료황갈반적료효현저。기작용궤제가능여자이순、란포자격소、촉황체생성소등자격소수평상관。
Objective To observe clinical effects of compound Muniziqi granules combined with vitamin A acid cream, and analyze its mechanism of action.Methods 76 cases of patients with chloasma treated in our hospital in March 2010 to February 2014 were selected.They were divided into two groups according to random number table method, 38 cases in each group.Observation group was given compound Muniziqi granules( three times per day,orally) combined with vitamin A acid cream(smear once respectively each morning and evening),control group was taken vitamin C 0.3 g and vitamin E 0.2 g ( three times per day, orally ) comined with vitamin A acid cream ( smear once respectively each morning and evening ) treatment.Observed clinical effects, scores of lesion area and color, detected serum estrogen level in both groups by radioimmunoassay. Results Compared with pre-treatment lesion area and color scores of observation group significantly reduced ( P<0.05 ).Compared with control group post-treatment, lesion area and color scores of observation group significantly reduced(P<0.05).Clinical effective rates of observation group and control group was 94.74%and 75.31%, respectively, the difference was significantly between two groups(P<0.05).Compared with pre-treatment, serum E2, FSH, LH levels of observation group were remarkably reduced(P<0.05).Compared with control group post-treatment, serum E2,FSH,LH levels of observation group significantly reduced(P<0.05).Conclusion The clinical effect of compound Muniziqi granules combined with vitamin A acid cream on chloasma is significant.Its mechanism may be relate to levels of estradiol, follicle-stimulating hormone and luteinizing hormone.
