中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
37期
6010-6016
,共7页
组织构建%组织工程%微管相关蛋白2%神经元%肿瘤
組織構建%組織工程%微管相關蛋白2%神經元%腫瘤
조직구건%조직공정%미관상관단백2%신경원%종류
背景：微管相关蛋白2是一种调节微管蛋白组成的重要调节因子，为微管相关蛋白的主要成员之一，在神经系统的发生及功能的维持上起着重要的作用，研究发现微管相关蛋白2能够促进神经损伤的修复与重建。<br> 目的：探讨总结微管相关蛋白2与神经损伤的关系及发挥作用的机制。<br> 方法：由第一作者运用计算机检索系统检索自1976年1月至2015年1月所有发表的与微管相关蛋白2的相关的文献，以“microtubule-associated protein-2(MAP-2)，nerve injury，progress”为检索词在同一领域选择近期发表或发表在权威杂志上的文章。排除重复性的文献及时间跨度比较长的文献，从检索结果中共选择了82篇文章进一步的分析。<br> 结果与结论：微管相关蛋白2主要存在于中枢神经系统神经元胞体和树突中。微管相关蛋白2参与神经损伤的修复过程，对神经元形态学和可塑性方面其促进作用。在神经损伤早期提升微管相关蛋白2的浓度可早期恢复神经元的功能。
揹景：微管相關蛋白2是一種調節微管蛋白組成的重要調節因子，為微管相關蛋白的主要成員之一，在神經繫統的髮生及功能的維持上起著重要的作用，研究髮現微管相關蛋白2能夠促進神經損傷的脩複與重建。<br> 目的：探討總結微管相關蛋白2與神經損傷的關繫及髮揮作用的機製。<br> 方法：由第一作者運用計算機檢索繫統檢索自1976年1月至2015年1月所有髮錶的與微管相關蛋白2的相關的文獻，以“microtubule-associated protein-2(MAP-2)，nerve injury，progress”為檢索詞在同一領域選擇近期髮錶或髮錶在權威雜誌上的文章。排除重複性的文獻及時間跨度比較長的文獻，從檢索結果中共選擇瞭82篇文章進一步的分析。<br> 結果與結論：微管相關蛋白2主要存在于中樞神經繫統神經元胞體和樹突中。微管相關蛋白2參與神經損傷的脩複過程，對神經元形態學和可塑性方麵其促進作用。在神經損傷早期提升微管相關蛋白2的濃度可早期恢複神經元的功能。
배경：미관상관단백2시일충조절미관단백조성적중요조절인자，위미관상관단백적주요성원지일，재신경계통적발생급공능적유지상기착중요적작용，연구발현미관상관단백2능구촉진신경손상적수복여중건。<br> 목적：탐토총결미관상관단백2여신경손상적관계급발휘작용적궤제。<br> 방법：유제일작자운용계산궤검색계통검색자1976년1월지2015년1월소유발표적여미관상관단백2적상관적문헌，이“microtubule-associated protein-2(MAP-2)，nerve injury，progress”위검색사재동일영역선택근기발표혹발표재권위잡지상적문장。배제중복성적문헌급시간과도비교장적문헌，종검색결과중공선택료82편문장진일보적분석。<br> 결과여결론：미관상관단백2주요존재우중추신경계통신경원포체화수돌중。미관상관단백2삼여신경손상적수복과정，대신경원형태학화가소성방면기촉진작용。재신경손상조기제승미관상관단백2적농도가조기회복신경원적공능。
BACKGROUND:Microtubule-associated protein-2 is a kind of important regulatory factor in regulating tubulin assembly. As one of the main members of microtubule-associated proteins, microtubule-associated protein-2 plays an important role in the repairing and development of the nervous system function. It has been found that microtubule-associated protein-2 can promote the repair and rebuilding of injured nerves. OBJECTIVE:To summarize the relationship between microtubule-associated protein-2 and nerve injury as wel as the mechanism of action. METHODS:The PubMed database and CNKI database were retrieved by the fist author for the articles related to microtubule-associated protein-2 published from January 1976 to January 2015. The key words were“microtubule-associated protein-2 (MAP-2), nerve injury, progress”in English and Chinese, respectively. In the same field, articles published recently or in authorized journals were preferred. Repetitive or old articles were excluded, and final y 82 articles were included in result analysis. RESULTS AND CONCLUSION:Microtubule-associated protein-2 is involved in nerve repair, and plays a promoting role in neuronal morphology and plasticity. To increase the concentration of microtubule-associated protein-2 contributes to the recovery of neurologic function in the early stage after nerve injury.
