CAJ | 학술논문

（目的）本试验旨在研究饮水中添加不同水平妥曲珠利对肉鸡血清生化指标的影响及停药后在肝脏沉积量的消减特点。(方法)选用288只1日龄AA肉鸡，随机分4组，每组6个重复。对照组(1组)饮用常规自来水，2组、3组和4组于8~10日龄饮水中分别添加妥曲珠利25、50、100mg/L，其它时间饮用常规自来水，试验期42d。(结果)结果表明，25mg/L妥曲珠利对肉鸡血清淀粉酶活性无显著影响(P>0.05)，可显著提高血清总蛋白和葡萄糖含量(P<0.05)；50mg/L 和100mg/L 妥曲珠利使血清淀粉酶活性和总蛋白含量显著降低(P<0.05)；25mg/L、50mg/L和100mg/L妥曲珠利使血清总超氧化物歧化酶活性显著或极显著下降(P<0.05或P<0.01)。肝脏中妥曲珠利沉积量具有显著剂量效应。停药7d，各试验组均已检测不出妥曲珠利。药物沉积量下降趋势符合指数函数模型，经预测模型计算得出，2组、3组、4组分别于停药后5.02、6.10、6.59d肝脏中沉积的妥曲珠利基本消失。（结论）综上所述，妥曲珠利对肉鸡血清生化指标的影响及其在肝脏中的沉积量均具有明显剂量效应，停药后肝脏药物的衰减速度较快。
（목적）본시험지재연구음수중첨가불동수평타곡주리대육계혈청생화지표적영향급정약후재간장침적량적소감특점。(방법)선용288지1일령AA육계，수궤분4조，매조6개중복。대조조(1조)음용상규자래수，2조、3조화4조우8~10일령음수중분별첨가타곡주리25、50、100mg/L，기타시간음용상규자래수，시험기42d。(결과)결과표명，25mg/L타곡주리대육계혈청정분매활성무현저영향(P>0.05)，가현저제고혈청총단백화포도당함량(P<0.05)；50mg/L 화100mg/L 타곡주리사혈청정분매활성화총단백함량현저강저(P<0.05)；25mg/L、50mg/L화100mg/L타곡주리사혈청총초양화물기화매활성현저혹겁현저하강(P<0.05혹P<0.01)。간장중타곡주리침적량구유현저제량효응。정약7d，각시험조균이검측불출타곡주리。약물침적량하강추세부합지수함수모형，경예측모형계산득출，2조、3조、4조분별우정약후5.02、6.10、6.59d간장중침적적타곡주리기본소실。（결론）종상소술，타곡주리대육계혈청생화지표적영향급기재간장중적침적량균구유명현제량효응，정약후간장약물적쇠감속도교쾌。
(Objective)The experiment was conducted to study the effects of Toltrazuril on serum biochemical indices and the dynamic elimination of its deposition in liver of broilers after withdrawal. (Method)288 1d AA broilers were randomly divided into 4 treatments with 6 replicates. The experimental groups (Group2,Group3 and Group4)were supplemented with 25 mg/L, 50 mg/L and 100 mg/L Toltrazuril in the conventional tap water respectively in 8~10 days old, the conventional tap water were supplied during other time., while the control group (Group1) was supplied with the conventional tap water. The experiment lasted for 42 days. (Result)The results showed that: 25 mg/L Toltrazuril had no significant effect on the activity of AMS (P>0.05),while the content of total protein and Glucose in serum increased significantly (P<0.05).The activity of AMS and the content of total protein of the two groups with 50 mg/L and 100 mg/L Toltrazuril were significantly lower than that of the control group (P<0.05).The activity of T-SOD of the groups with 25 mg/L, 50 mg/L and 100 mg/L Toltrazuril were significantly lower than that of the control group (P<0.05 or P<0.01). The deposition amount of Toltrazuril in broiler's liver appeared obviously to be correlated to the dosage of it. Toltrazuril could not be detected at the seventh day after withdrawal. With the extension of time after withdrawal, the elimination trend of Toltrazuril in liver accorded with index function model. According to the model prediction, Toltrazuril's deposition amount in liver of Group2, Group3 and Group4 almost disappeared at 5.02 day, 6.10 day and 6.59 day after withdrawal respectively. (Conclusion)In conclusion, there was obvious dose-effect correlation between the dosage of Toltrazuril and broilers ' serum biochemical indices, so was the Toltrazuril ' s deposition amount in liver. The elimination of Toltrazuril in liver was fast after withdrawal.