CAJ | 학술논문

目的：探讨三联疗法与序贯疗法在长期服用拜阿司匹林者根除幽门螺杆菌的疗效。方法收集收治的长期服用拜阿司匹林的幽门螺旋杆菌感染患者52例，根据用药不同分为三联组和序贯组，每组各26例，分别给予相应的药物治疗，治疗结束后，对所有患者的血清胃蛋白酶原含量、Hp-IgG抗体水平及幽门螺旋杆菌清除率进行检测。结果治疗后，与三联组比较，序贯组患者血清PGⅠ、PGⅡ含量较低，PGⅠ／PGⅡ较高，差异具有统计学意义（P＜0.05）；序贯组患者的血清Hp-IgG抗体水平较低（P＜0.05）；序贯组患者的Hp清除率较高（ P＜0.05）。结论与三联疗法相比，序贯疗法能够更好的降低血清PGⅠ、PGⅡ以及Hp-IgG水平，提高Hp清除率，对临床有指导意义。
목적：탐토삼련요법여서관요법재장기복용배아사필림자근제유문라간균적료효。방법수집수치적장기복용배아사필림적유문라선간균감염환자52례，근거용약불동분위삼련조화서관조，매조각26례，분별급여상응적약물치료，치료결속후，대소유환자적혈청위단백매원함량、Hp-IgG항체수평급유문라선간균청제솔진행검측。결과치료후，여삼련조비교，서관조환자혈청PGⅠ、PGⅡ함량교저，PGⅠ／PGⅡ교고，차이구유통계학의의（P＜0.05）；서관조환자적혈청Hp-IgG항체수평교저（P＜0.05）；서관조환자적Hp청제솔교고（ P＜0.05）。결론여삼련요법상비，서관요법능구경호적강저혈청PGⅠ、PGⅡ이급Hp-IgG수평，제고Hp청제솔，대림상유지도의의。
Objective To analysis curative effect of triple therapy and sequential therapy for eradication of Helicobacter pylori in patients with long-term aspirin use.Methods 52 patients with long-term aspirin use who were diagnosed with helicobacter pylori infection were collected.All patients were divided into sequential group and triple group according to different drugs classified, each 26 cases in each group were given corresponding drug treatment, after the end of treatment, the serum pepsinogen, Hp-IgG antibody levels and Helicobacter pylori clearance rate were detected in all patients. Results After treatment, compared with the triple Group, in the sequential group, the levels of serum PG I and PG II were lower, and PGⅠ/PGⅡwas higher, and the differences were statistically significant (P<0.05);the serum Hp-IgG antibody levels were lower in the sequential group (P<0.05);the Hp clearance rate of patients in the sequential group was higher (P<0.05).Conclusion Compared with triple therapy, sequential therapy can lower serum PG, PG II and Hp-IgG levels, and improve the Hp clearance rate and clinical efficacy, have guiding significance to clinical.