CAJ | 학술논문

目的：了解2012～2014年该院铜绿假单胞菌临床感染分布及耐药性情况。方法对分离得到的铜绿假单胞菌进行鉴定及抗菌药物敏感性试验，数据使用W H O N E T 5．6软件进行统计分析。结果2012～2014年共分离得到1123株铜绿假单胞菌，标本来源主要为痰（753株，67．1％）、伤口分泌物（179株，15．9％）、中段尿（95株，8．5％），科室来源主要为神经外科（255株，22．7％）、呼吸内科（238株，21．2％）、IC U （177株，15．8％）、创伤骨科（84株，7．5％）。1123株铜绿假单胞菌对哌拉西林（29．4％）、哌拉西林／他唑巴坦（20．9％）、头孢吡肟（27．8％）、左氧氟沙星（29．9％）、氨基糖苷类（15．8％～25．8％）具有较低的耐药率，对氨曲南（47．7％）耐药率最高。分离自痰标本的铜绿假单胞菌耐药率明显高于总耐药率。2012～2014年多重耐药及泛耐药铜绿假单胞菌检出数量逐年增加。结论日常工作中应加强铜绿假单胞菌的耐药监测，减少及预防多重耐药和泛耐药菌的产生。
목적：료해2012～2014년해원동록가단포균림상감염분포급내약성정황。방법대분리득도적동록가단포균진행감정급항균약물민감성시험，수거사용W H O N E T 5．6연건진행통계분석。결과2012～2014년공분리득도1123주동록가단포균，표본래원주요위담（753주，67．1％）、상구분비물（179주，15．9％）、중단뇨（95주，8．5％），과실래원주요위신경외과（255주，22．7％）、호흡내과（238주，21．2％）、IC U （177주，15．8％）、창상골과（84주，7．5％）。1123주동록가단포균대고랍서림（29．4％）、고랍서림／타서파탄（20．9％）、두포필우（27．8％）、좌양불사성（29．9％）、안기당감류（15．8％～25．8％）구유교저적내약솔，대안곡남（47．7％）내약솔최고。분리자담표본적동록가단포균내약솔명현고우총내약솔。2012～2014년다중내약급범내약동록가단포균검출수량축년증가。결론일상공작중응가강동록가단포균적내약감측，감소급예방다중내약화범내약균적산생。
Objective To investigate clinical distribution and drug resistance of Pseudomonas aeruginosa isola‐ted from 2012 to 2014 .Methods All of the isolated Pseudomonas aeruginosa strains were identified and tested drug susceptibility .Data were analyzed by using the software WHONET5 .6 .Results 1 123 strains of Pseudomonas aeruginosa were isolated from 2012 to 2014 ,most of which isolated from sputum (n=753 ,67 .1% ) ,wound secretion (n=179 ,15 .9% ) ,urine (n=95 ,8 .5% ) .And the Pseudomonas aeruginosa strains were mainly distributed in neuro‐surgery (n=255 ,22 .7% ) ,respiratory medicine (n=238 ,21 .2% ) ,ICU (n=177 ,15 .8% ) ,orthopedic trauma (n=84 ,7 .5% ) .All of the 1 123 strains of Pseudomonas aeruginosa had low drug resistance rates to piperacillin (29 .4% ) ,piperacillin/tazobactam (20 .9% ) ,cefepime (27 .8% ) ,levofloxacin (29 .9% ) ,aminoglycosides (15 .8% -25 .8% ) ,and had the highest drug resistance rate to aztreonam (47 .7% ) .The drug resistance rates of Pseudomonas aeruginosa isolated from sputum samples were significantly higher than the overall resistance rate .The numbers of multi‐drug resistant and pan‐drug resistant Pseudomonas aeruginosa significantly increased from 2012 to 2014 .Con‐clusion Monitoring drug resistance of Pseudomonas aeruginosa should be strengthened in daily work ,so as to reduce and prevent multiple drug resistance and pan‐resistant bacteria .