CAJ | 학술논문

目的：探讨荆芥炭方联合雷公藤多苷片治疗进行性色素性紫癜性皮肤病的临床效果。方法选取2012年1月~2014年12月我院收治的100例进行性色素性紫癜性皮肤病患者作为研究对象,按照随机分配的原则,将患者分为对照组和观察组,每组50例。对照组给予肝素钠乳膏治疗,观察组给予荆芥炭方联合雷公藤多苷片治疗。每组患者均进行为期1个月的治疗。治疗1个月后,比较两组患者的治疗效果和不良反应发生情况。结果对照组的总有效率为64%,观察组为86%,观察组的治疗效果明显优于对照组(字2=6.4533,P=0.011)。对照组中共有18例患者发生不良反应,不良反应发生率为36%,观察组中共有9例发生不良反应,不良反应发生率为18%,观察组患者的不良反应发生情况明显低于对照组(字2=4.1096,P=0.043)。结论荆芥炭方联合雷公藤多苷片治疗进行性色素性紫癜性皮肤病,不仅具有显著的临床效果,还具有较高的安全性,具有较高的临床价值,可考虑被广泛应用于该病的治疗中。
목적：탐토형개탄방연합뢰공등다감편치료진행성색소성자전성피부병적림상효과。방법선취2012년1월~2014년12월아원수치적100례진행성색소성자전성피부병환자작위연구대상,안조수궤분배적원칙,장환자분위대조조화관찰조,매조50례。대조조급여간소납유고치료,관찰조급여형개탄방연합뢰공등다감편치료。매조환자균진행위기1개월적치료。치료1개월후,비교량조환자적치료효과화불량반응발생정황。결과대조조적총유효솔위64%,관찰조위86%,관찰조적치료효과명현우우대조조(자2=6.4533,P=0.011)。대조조중공유18례환자발생불량반응,불량반응발생솔위36%,관찰조중공유9례발생불량반응,불량반응발생솔위18%,관찰조환자적불량반응발생정황명현저우대조조(자2=4.1096,P=0.043)。결론형개탄방연합뢰공등다감편치료진행성색소성자전성피부병,불부구유현저적림상효과,환구유교고적안전성,구유교고적림상개치,가고필피엄범응용우해병적치료중。
Objective To explore the clinical effect of Carbonized catnip prescription combined with Tripterygium gly-cosides tablet in the treatment of progressive pigmentary purpuric dermatosis. Methods One hundred patients with pro-gressive pigmentary purpuric dermatosis admitted into our hospital from January 2012 to December 2014 were selected as the study subjects and divided into control group and observation group according to the random allocation principle, and there were 50 patients in each group.Control group was given heparin sodium cream treatment and observation group was given Carbonized catnip prescription combined with Tripterygium glycosides tablet treatment.Both groups of patients were treated for 1 month.After 1 moth treatment,the clinical treatment effect and occurrence of adverse reaction between two group groups was compared respectively. Results The total effective rate of control group was 64% and that of observation group was 86%,the observation group was significantly better than the control group in the clinical effect (χ2=6.4533,P=0.011).Adverse reactions occurred in 18 patients of control group,and the incidence rate of adverse reaction was 36% in patients of control group,and adverse reaction occurred in 9 patients of observation group,and the incidence rate of adverse reaction was 18%,the observation group was significantly lower than that of control group in the occurrence rate of adverse reaction (χ2=4.1096,P=0.043). Conclusion Carbonized catnip prescription combined with Tripterygium glycosides tablet in the treatment of progressive pigmentary purpuric dermatosis not only shows remark-able treatment effect,but also has a higher safety and clinical value,which can be widely used in the clinical treatment of progressive pigmentary purpuric dermatosis.