CAJ | 학술논문

背景：有研究表明，中成药复明颗粒对治疗是神经损伤具有一定的疗效，但仍需进行大量的实验研究进行验证。目的：以应力松弛实验的方法验证中成药复明颗粒干预治疗视神经损伤的效果。方法：以钳夹法造成家兔视神经损伤，用复明颗粒稀释灌胃干预，并设模型组和正常对照组作对比，连续给药30 d后取各组动物视神经进行应力松弛实验和组织形态观察。结果与结论：正常对照组视神细胞核分别均匀，无明显水肿及增大，无炎症细胞，轴突等内容物形态清晰。模型组视神经纤维排列稀疏，结构模糊，轴突、核碎裂轴突等内容物形态发生了改变。复明颗粒治疗组视神经横断面较大面积神经纤维排列较密集，多数轴突形态正常。视神经7200 s应力下降量和和应力松弛下降值均为正常对照组>复明颗粒治疗组>模型组(P <0.05)。结果证实，中成药复明颗粒加快了损伤视神经轴浆恢复，使轴突形态恢复正常，有利于损伤视神经的恢复。
배경：유연구표명，중성약복명과립대치료시신경손상구유일정적료효，단잉수진행대량적실험연구진행험증。목적：이응력송이실험적방법험증중성약복명과립간예치료시신경손상적효과。방법：이겸협법조성가토시신경손상，용복명과립희석관위간예，병설모형조화정상대조조작대비，련속급약30 d후취각조동물시신경진행응력송이실험화조직형태관찰。결과여결론：정상대조조시신세포핵분별균균，무명현수종급증대，무염증세포，축돌등내용물형태청석。모형조시신경섬유배렬희소，결구모호，축돌、핵쇄렬축돌등내용물형태발생료개변。복명과립치료조시신경횡단면교대면적신경섬유배렬교밀집，다수축돌형태정상。시신경7200 s응력하강량화화응력송이하강치균위정상대조조>복명과립치료조>모형조(P <0.05)。결과증실，중성약복명과립가쾌료손상시신경축장회복，사축돌형태회복정상，유리우손상시신경적회복。
BACKGROUND:Many studies have shown that Chinese medicineFuming granules have certain curative effects on optic nerve injury, but a large number of experimental studies are stil needed to verify. OBJECTIVE:To verify the effect of Chinese medicineFuming granules on optic nerve injury by the method of stress relaxation experiments. METHODS: The animal models of optic nerve injury were established by the clamping method. Rats were intervened withFuming granules by intragastric administration. Model group and normal control group were set for comparison. After 30 days of successive administration, optic nerve injury received stress relaxation experiments in each group, and histomorphology was observed. RESULTS AND CONCLUSION:In the normal control group, the optic nerve nuclei distributed uniformly without edema, augmentation or inflammatory cels, and the axon and other contents had a clear structure. In the model group, the optic nerve fiber arranged sparsely, presented unclear structure, and axon, karyorrhexis and the other contents changed. In theFuming granule group, the transect of optic nerve which arranged densely had large area, and most of the axon had a normal structure. The decreases in stress at 7 200 s and stress relaxation were as folows: normal control group > fuming granule group > model group (P < 0.05). Results confirmed that Chinese medicineFuming granule accelerates the recovery of axoplasm of injured optic nerve, restores the morphology of axons, and contributes to the recovery of injured optic nerve.