CAJ | 학술논문

目的：探讨双歧杆菌四联活菌片联合头孢克肟对细菌性肠炎患者C反应蛋白（ C reactive protein，CRP）、铜蓝蛋白（Ceruloplasmin ，CER）、触珠蛋白（haptoglobin，HPT）、α1酸性糖蛋白（α1-acid glycoprotein ，AAG）的影响。方法收集收治的急性细菌性肠炎的患者58例，随机分为实验组和对照组，每组各29例，在常规治疗基础上，对照组患者给予头孢克肟治疗，实验组患者在对照组基础上给予双歧杆菌四联活菌片口服治疗，治疗结束后，对所有患者的血清CRP、CER、HPT、AAG水平及临床疗效进行检测。结果治疗后，2组患者的CRP、CER、HPT、AAG水平均低于治疗前（ P＜0.05），与对照组比较，实验组患者血清CRP、CER、HPT、AAG水平较低，差异具有统计学意义（P＜0.05）；实验组患者的总有效率较高（χ2＝4.35，P＜0.05）。结论双歧杆菌四联活菌片联合头孢克肟能够明显降低细菌性肠炎患者血清CRP、CER、HPT、AAG水平，提高临床疗效，对临床有指导意义。
목적：탐토쌍기간균사련활균편연합두포극우대세균성장염환자C반응단백（ C reactive protein，CRP）、동람단백（Ceruloplasmin ，CER）、촉주단백（haptoglobin，HPT）、α1산성당단백（α1-acid glycoprotein ，AAG）적영향。방법수집수치적급성세균성장염적환자58례，수궤분위실험조화대조조，매조각29례，재상규치료기출상，대조조환자급여두포극우치료，실험조환자재대조조기출상급여쌍기간균사련활균편구복치료，치료결속후，대소유환자적혈청CRP、CER、HPT、AAG수평급림상료효진행검측。결과치료후，2조환자적CRP、CER、HPT、AAG수평균저우치료전（ P＜0.05），여대조조비교，실험조환자혈청CRP、CER、HPT、AAG수평교저，차이구유통계학의의（P＜0.05）；실험조환자적총유효솔교고（χ2＝4.35，P＜0.05）。결론쌍기간균사련활균편연합두포극우능구명현강저세균성장염환자혈청CRP、CER、HPT、AAG수평，제고림상료효，대림상유지도의의。
Objective To analysis effect of Bifidobacterium tetravaccine tablets ( live ) combined with cefixime on C-reactive protein, ceruloplasmin, haptoglobin and α1-acid glycoprotein in patients with Bacterial enteritis.Methods 58 patients who were diagnosed with Bacterial enteritis were collected.All patients were randomly divided into experimental group and control group, 29 cases in each group, On the basis of conventional treatment, the control group was treated with cefixime, and the experimental group was treated with Bifidobacterium tetravaccine tablets ( live) on the basis of control group.After treatment, the serum levels of CRP, CER, HPT, AAG and clinical curative effect were detected in all patients.Results After treatment, CRP, CER, HPT, AAG levels were lower than before treatment (P<0.05),compared with control group, CRP, CER, HPT, AAG levels were lower than in the experimental group( P<0.05);the total effective rate was higher in the experimental group (χ2 =4.35, P<0.05).Conclusion Bifidobacterium tetravaccine tablets(live) combined with cefixime can significantly reduce the serum CRP, CER, HPT, AAG levels in patients with bacteria enteritis, improve the clinical efficacy, have guidance significance for clinic.