CAJ | 학술논문

背景：颈内动脉虹吸部走行弯曲、周围结构复杂，解剖学、影像学测量研究较多，并成为相关领域的研究热点，但目前对颈内动脉虹吸部血流动力学的相关研究报道较少，利用有限元分析技术，为相关动力学研究提供了基础。目的：明确颈内动脉虹吸部正常及狭窄血液动力学特点，探讨血流动力学的影响因素。<br>　　方法：利用64排螺旋CT扫描获得DICOM数据实现颈内动脉虹吸部有限元建模，分别在Mimics 10.01软件上进行三维模型的实体构建，用ANSYS 13.0 CFX软件模拟仿真人类颈内动脉虹吸部正常及狭窄后血流，观察正常血流及狭窄后血流动力学的改变，分析其特点与差异。<br>　　结果与结论：颈内动脉虹吸部正常血流在弯曲的虹吸部呈层流状态，但经过两个折角时血流发生旋动与湍流。血流经折角内弯区较快，外弯区较慢，速度越慢湍流越明显；折角处剪切力较小，同时折角外弯区剪切力较内弯区小。动脉狭窄后血流经狭窄区速度加快，狭窄下游形成湍流及低剪切力区；随狭窄程度增大，湍流、低剪切力区域扩大，中央性狭窄比偏心性狭窄影响大。结果证实，颈内动脉虹吸部弯曲、管腔狭窄直接影响湍流及低剪切力区形成，以外弯区及中央性狭窄影响明显。
배경：경내동맥홍흡부주행만곡、주위결구복잡，해부학、영상학측량연구교다，병성위상관영역적연구열점，단목전대경내동맥홍흡부혈류동역학적상관연구보도교소，이용유한원분석기술，위상관동역학연구제공료기출。목적：명학경내동맥홍흡부정상급협착혈액동역학특점，탐토혈류동역학적영향인소。<br>　　방법：이용64배라선CT소묘획득DICOM수거실현경내동맥홍흡부유한원건모，분별재Mimics 10.01연건상진행삼유모형적실체구건，용ANSYS 13.0 CFX연건모의방진인류경내동맥홍흡부정상급협착후혈류，관찰정상혈류급협착후혈류동역학적개변，분석기특점여차이。<br>　　결과여결론：경내동맥홍흡부정상혈류재만곡적홍흡부정층류상태，단경과량개절각시혈류발생선동여단류。혈류경절각내만구교쾌，외만구교만，속도월만단류월명현；절각처전절력교소，동시절각외만구전절력교내만구소。동맥협착후혈류경협착구속도가쾌，협착하유형성단류급저전절력구；수협착정도증대，단류、저전절력구역확대，중앙성협착비편심성협착영향대。결과증실，경내동맥홍흡부만곡、관강협착직접영향단류급저전절력구형성，이외만구급중앙성협착영향명현。
BACKGROUND:The siphon of internal carotid artery is a complex of bending and surrounding structure, which has become a research hot in the field of medical imaging and regional anatomy. There is little research on the hemodynamics of internal carotid artery. Finite element analysis provides the basis for the related dynamics research. OBJECTIVE:To explicit the hemodynamic characteristics of the normal and stenosis internal carotid artery, and to explore the relevant influential factors. METHODS:Finite element model of the siphon of internal carotid artery was built based on 64-slice spiral CT data, and then, three-dimensional models were constructed using Mimics 10.01 software. There were simulations of the normal and post-stenosis blood flows with ANSYS 13.0 CFX software, to observe the changes of hemodynamics, and to analyze their characteristics and differences. RESULTS AND CONCLUSION:The normal blood flow at the siphon of internal carotid artery was in a laminar state, but rotation and turbulent flow formed at the two angle regions. The velocity of external bending zone was slower than that of the internal. The slower was the velocity, the more obvious was the turbulence. The wal shear force decreased at the angle regions, and the wal shear force of external bending zone was smal er than that of the internal. At the region of arterial stenosis, the blood flow was sped, and at the downstream, turbulent flow and low zone of wal shear force were formed. With the increase of stenosis severity, the turbulent flow and low wal shear force area were expanded. Central stenosis showed more obvious effects than the eccentric one. The degree of stenosis and bending at the siphon of internal carotid artery can directly influence the formation of turbulent flow and low wal shear force area, which are more obvious at the external bending zone and central stenosis.