CAJ | 학술논문

背景：早期筛查和诊断可有效降低结直肠癌（CRC）相关死亡率，并可提高患者总体生存率。目前的 CRC 早期筛查方法主要包括粪便隐血试验和结肠镜检查。粪便隐血试验敏感性低，假阳性较多，而金标准结肠镜检查为有创性检查，患者依从性较低。因此，目前临床亟需寻找有效且简便的 CRC 早期筛查和诊断方法。血浆 SEPT9基因甲基化检测是近年来国外已开始应用的新型非创伤性 CRC 早期筛查和诊断方法之一，此法较为准确、简便，适合大规模筛查和早期诊断。本文就血浆 SEPT9基因甲基化检测对 CRC 的诊断价值以及相关研究进展进行概述。
배경：조기사사화진단가유효강저결직장암（CRC）상관사망솔，병가제고환자총체생존솔。목전적 CRC 조기사사방법주요포괄분편은혈시험화결장경검사。분편은혈시험민감성저，가양성교다，이금표준결장경검사위유창성검사，환자의종성교저。인차，목전림상극수심조유효차간편적 CRC 조기사사화진단방법。혈장 SEPT9기인갑기화검측시근년래국외이개시응용적신형비창상성 CRC 조기사사화진단방법지일，차법교위준학、간편，괄합대규모사사화조기진단。본문취혈장 SEPT9기인갑기화검측대 CRC 적진단개치이급상관연구진전진행개술。
Screening and diagnosis of early colorectal cancer(CRC)can reduce CRC mortality and improve overall survival. Currently,the major screening methods for early CRC include fecal occult blood test(FOBT)and colonoscopy. FOBT exhibits low sensitivity with high false positive rate,while the gold standard -- colonoscopy is invasive and with low compliance. Therefore,a convenient and effective screening and diagnostic method for early CRC is urgently needed. Plasma SEPT9 gene methylation assay is a new non-invasive screening and diagnostic method for early CRC used clinically in recent years,it exhibits high accuracy,and is convenient for mass screening and diagnosis of early CRC. This article reviewed the research progress and diagnostic value of plasma SEPT9 gene methylation assay for CRC.