CAJ | 학술논문

目的:探讨点阵CO2激光治疗兔耳增生性瘢痕中P物质的变化情况.方法:建立兔耳增生性瘢痕模型,点阵CO2激光治疗后,免疫组化检测P物质的表达.结果:点阵CO2激光治疗后第1天P物质表达评分为1.33±0.50,第4天为7.67±1.58,治疗后第7天评分为4.00±1.41,第14天评分为1.56±0.88,第4天与第1天比较,第7天与第4天比较,第14天与第7天比较,差异均有统计学意义(P<0.05).结论:点阵CO2激光治疗兔耳增生性瘢痕后P物质表达先升高后降低,这可能与点阵CO2激光参与创面再生修复有关.
목적:탐토점진CO2격광치료토이증생성반흔중P물질적변화정황.방법:건립토이증생성반흔모형,점진CO2격광치료후,면역조화검측P물질적표체.결과:점진CO2격광치료후제1천P물질표체평분위1.33±0.50,제4천위7.67±1.58,치료후제7천평분위4.00±1.41,제14천평분위1.56±0.88,제4천여제1천비교,제7천여제4천비교,제14천여제7천비교,차이균유통계학의의(P<0.05).결론:점진CO2격광치료토이증생성반흔후P물질표체선승고후강저,저가능여점진CO2격광삼여창면재생수복유관.
Objective To investigate the change of substance P after fractional CO2 laser on the treatment of hypertrophic scars in rabbit ear. Methods The model of hypertrophic scars in rabbit ear was established,then expression of substance P were tested by immunohistochemical after fractional CO2 laser on the treatment of hypertrophic scars in rabbit ear. Results The score of substance P expression at 1st day was 1.33 ± 0.50,the score of expression at 4th day was 7.67 ± 1.58, xpression score at 7th day was 4.00±1.41,the score of expression at 14th day was 1.56±0.88,there is statistical significance between the two days(P<0.05). Conclusions The change of substance P after fractional CO2 laser on the treatment of hypertrophic scars in rabbit ear shows a trend from rise to decline,it may be related to fractional CO2 laser participating in wound regeneration in situ.