CAJ | 학술논문

目的：探讨帕罗西汀联合小剂量奥氮平治疗抑郁症伴失眠患者临床疗效。方法：收治抑郁症伴失眠患者104例，随机分为对照组和试验组各52例，对照组采用小剂量奥氮平治疗，试验组在对照组的基础上加入帕罗西汀治疗，比较两组治疗效果。结果：试验组总有效率98.1%，明显高于对照组的80.8%(P＜0.05)；治疗后，两组患者的HAMD 评分、HAMA 评分、PSQI 评分均比治疗前有明显改善(P＜0.05)；试验组治疗后的 HAMD 评分、HAMA 评分、PSQI评分均明显优于对照组(P＜0.05)。结论：采用帕罗西汀联合小剂量奥氮平治疗抑郁症伴失眠患者可以明显地改善患者的症状，提高患者的睡眠质量，提高患者的生活质量。
목적：탐토파라서정연합소제량오담평치료억욱증반실면환자림상료효。방법：수치억욱증반실면환자104례，수궤분위대조조화시험조각52례，대조조채용소제량오담평치료，시험조재대조조적기출상가입파라서정치료，비교량조치료효과。결과：시험조총유효솔98.1%，명현고우대조조적80.8%(P＜0.05)；치료후，량조환자적HAMD 평분、HAMA 평분、PSQI 평분균비치료전유명현개선(P＜0.05)；시험조치료후적 HAMD 평분、HAMA 평분、PSQI평분균명현우우대조조(P＜0.05)。결론：채용파라서정연합소제량오담평치료억욱증반실면환자가이명현지개선환자적증상，제고환자적수면질량，제고환자적생활질량。
Objective:To explore the clinical effect of paroxetine combined with small dose of olanzapine in the treatment of patients with depression and insomnia.Methods:104 depression patients with insomnia were selected.They were randomly divided into the control group and the experimental group with 52 cases in each.The control group was given small dose olanzapine,and the experimental group was given paroxetine on the basis of the control group,then we compared two groups of treatment effect. Results:In the experimental group,the total effective rate of 98.1% was significantly higher than 80.8% of the control group(P<0.05).After treatment,HAMD score,HAMA score,PSQI score of the two groups was significantly improved(P<0.05),and HAMD score,HAMA score and PSQI score in the experimental group were significantly better than the control group(P<0.05). Conclusion:Paroxetine combined with small dose of olanzapine in the treatment of patients with depression and insomnia can significantly improve the symptoms of patients,improve the quality of sleep,and improve the quality of life of patients.