CAJ | 학술논문

目的：探讨硫酸镁联合钙离子通道拮抗剂对妊娠期高血压患者血清胱抑素C（ cystatin C）、尿酸、甲胎蛋白（ alpha fetal protein，AFP）及尿转铁蛋白（ transferrin，TRF）水平的影响及意义。方法选取温州医科大学附属第三医院2013年1月～2014年10月产科收治的75例妊娠期高血压患者，随机分为2组，对照组37例行临床常规治疗；实验组38例，在对照组基础上加用硫酸镁和钙离子通道拮抗剂治疗。检测2组患者血清胱抑素C、尿酸、甲胎蛋白及尿转铁蛋白水平变化，比较2组临床疗效。结果与对照组比较，实验组Cys C、尿酸水平较低（P＜0.05），血清AFP水平、尿TRF水平较低（P＜0.05），血清血细胞比容、血液粘度及红细胞聚集指数较低（P＜0.05），总有效率明显高于对照组（P＜0.05）。结论硫酸镁联合钙离子通道拮抗剂对妊娠期高血压疾病患者治疗有较好的临床疗效，能有效改善血液粘度，降低血清Cys C、尿酸、AFP和尿TRF水平。
목적：탐토류산미연합개리자통도길항제대임신기고혈압환자혈청광억소C（ cystatin C）、뇨산、갑태단백（ alpha fetal protein，AFP）급뇨전철단백（ transferrin，TRF）수평적영향급의의。방법선취온주의과대학부속제삼의원2013년1월～2014년10월산과수치적75례임신기고혈압환자，수궤분위2조，대조조37례행림상상규치료；실험조38례，재대조조기출상가용류산미화개리자통도길항제치료。검측2조환자혈청광억소C、뇨산、갑태단백급뇨전철단백수평변화，비교2조림상료효。결과여대조조비교，실험조Cys C、뇨산수평교저（P＜0.05），혈청AFP수평、뇨TRF수평교저（P＜0.05），혈청혈세포비용、혈액점도급홍세포취집지수교저（P＜0.05），총유효솔명현고우대조조（P＜0.05）。결론류산미연합개리자통도길항제대임신기고혈압질병환자치료유교호적림상료효，능유효개선혈액점도，강저혈청Cys C、뇨산、AFP화뇨TRF수평。
Objective To explore the effect of magnesium sulfate combined with calcium channel blockers on cystatin C, uric acid, alpha fetal protein and urinary transferrin in patients with hypertension pregnancy.Methods 75 cases with hypertension of pregnancy were selected and divided into two groups, control group(n=37) were treated with conventional therapy, experiment group(n=38) were treated with magnesium sulfate combined with calcium channel blockers on the basis of control group.Cystatin C, uric acid, alpha fetal protein and urinary transferrin were compared after treatment between two groups.Results Compared with control group, Cys C, uric acid, serum AFP l, urinary TRF levels were all lower in experiment group( P<0.05), serum hematocrit, whole blood viscosity and erythrocyte aggregation index were all lower in experiment group(P<0.05).The total efficiency of experiment group was significantly higher than control group (P<0.05).Conclusion Magnesium sulfate combined with calcium channel antagonists in treatment of hypertensive disorder complicating pregnancy patients has good clinical curative effect, can effectively improve blood viscosity, reduce serum Cys C, UA, AFP and urinary TRF level.