多重置换扩增在地中海贫血植入前遗传学诊断中的应用
다중치환확증재지중해빈혈식입전유전학진단중적응용
Multiple displacement amplification and its application in preimplantation genetic diagnosis of thalassemia
  • 万方数据
    中国临床新医学 중국림상신의학
    Chinese Journal of New Clinical Medicine
    2015年 10期 1004-1007 ,共4页

    王世凯%黄莉(综述)%何冰(审校)

    왕세개%황리(종술)%하빙(심교)

    多重置换扩增%植入前遗传学诊断%地中海贫血 多重置換擴增%植入前遺傳學診斷%地中海貧血
    다중치환확증%식입전유전학진단%지중해빈혈
    Multiple displacement amplification (MDA)%Preimplantation genetic diagnosis(PGD)%Thalassemia
    多重置换扩增（ MDA）技术作为一种全新的全基因组扩增技术，为单细胞的后续检测提供了足够和稳定的DNA，在地中海贫血植入前遗传学诊断的实验研究和临床应用中取得了较大进展。该文就MDA的原理、技术特点及其在地中海贫血植入前遗传学诊断中的应用研究进展进行综述。
    다중치환확증（ MDA）기술작위일충전신적전기인조확증기술，위단세포적후속검측제공료족구화은정적DNA，재지중해빈혈식입전유전학진단적실험연구화림상응용중취득료교대진전。해문취MDA적원리、기술특점급기재지중해빈혈식입전유전학진단중적응용연구진전진행종술。
    As an entirely new genome amplification technology to provide sufficient and stable DNA for sub-sequent detection of single cell, multiple displacement amplification( MDA) has acquired a great progress in experi-mental research and clinical application in preimplantation genetic diagnosis of thalassemia.In this review, we intro-duce the principles of MDA, technical characteristics and research progress in preimplantation genetic diagnosis of thalassemia.
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