CAJ | 학술논문

目的：：探讨高龄孕妇(≥35岁)进行血清学唐氏筛查的价值及其与产前诊断中的意义。方法：回顾性分析了2010年1月~2014年12月到某院检查的具有产前诊断指证的高龄孕妇750例的临床资料,对唐氏筛查高风险孕妇进行无创基因检测,后对更有可疑的孕妇进行羊水穿刺进一步确诊。结果：与2012年以前相比,2013年以后行唐氏筛查的人数逐渐增加,而唐氏综合症出生率显著减少,差异有统计学意义(P <0.05)。结论：对高龄孕妇行血清学唐氏筛查具有较高的价值,对产前诊断具有十分重要的意义。
목적：：탐토고령잉부(≥35세)진행혈청학당씨사사적개치급기여산전진단중적의의。방법：회고성분석료2010년1월~2014년12월도모원검사적구유산전진단지증적고령잉부750례적림상자료,대당씨사사고풍험잉부진행무창기인검측,후대경유가의적잉부진행양수천자진일보학진。결과：여2012년이전상비,2013년이후행당씨사사적인수축점증가,이당씨종합증출생솔현저감소,차이유통계학의의(P <0.05)。결론：대고령잉부행혈청학당씨사사구유교고적개치,대산전진단구유십분중요적의의。
Objective:To investigate the value of serologic Down's screening to elderly pregnant woman (aged above 35 years old)and its significance to their prenatal diagnosis.Methods:Make retrospective analysis on 750 cases of elderly pregnant women with the indicators of prenatal diagnosis who received examination in some hospital during the period from January 2010 to December 2014 ,made non-invasive gene test on those pregnant women in high risk according to Down's screening,and then carry out amniocentesis for the suspec-ted pregnant women to make further confirmed diagnosis.Results:To compare with that before 2012,the number of pregnant women receiving Down's screening are has been increasing annually since 2013 ,and the occurrence of Down's syndrome is decreasing year by year,the differences were statistically significant(P <0. 05).Conclusion:It is of great value for elderly pregnant woman to have serologic Down's screening,and it is significant to prenatal diagnosis.