CAJ | 학술논문

逍遥散对中老年女性膝关节骨关节炎患者性激素水平影响的临床研究
소요산대중노년녀성슬관절골관절염환자성격소수평영향적림상연구
Clinical study of the effect of free and unfettered San on the sex hormone levels in the elderly women with knee osteoarthritis

万方数据

世界最新医学信息文摘（连续型电子期刊） 세계최신의학신식문적（련속형전자기간）
World Latest Medicine Information
2015年 65期 64-65 ,共2页

戴七一%谈驰%王雄%黎强%覃学流%王新%容向宾%龙飞攀%梁庆华%覃杰%袁经阳%吴兆沛

대칠일%담치%왕웅%려강%담학류%왕신%용향빈%룡비반%량경화%담걸%원경양%오조패

膝关节骨关节炎%中老年女性%性激素%中医药%临床研究膝關節骨關節炎%中老年女性%性激素%中醫藥%臨床研究
슬관절골관절염%중노년녀성%성격소%중의약%림상연구
Knee Osteoarthritis%Menopausal Women%Sex Hormone Level%Traditional Chinese Medicine%Clinical Research

目的：通过观察逍遥散对中老年女性膝关节骨关节炎（膝OA）患者性激素水平的影响，探讨逍遥散治疗膝OA的可能作用机制。方法选取我院骨科门诊女性膝OA患者60例，随机分为中药组、西医组各30例。中药组服用逍遥丸9周、西药组服用硫酸氨基葡萄糖胶囊9周，治疗前、后与体检中心选择的30例50~65岁无膝关节症状的女性体检人员均空腹抽血检测雌二醇、睾丸酮含量，数据经统计学处理。结果膝OA组患者年龄较正常组小，血清雌二醇含量较正常组低；中药组治疗后血清雌二醇含量明显升高，并明显高于西药组(P>0.05)。结论逍遥散通过影响中老年女性雌二醇含量变化可能为膝OA患者的治疗提供一种更理想的选择。
목적：통과관찰소요산대중노년녀성슬관절골관절염（슬OA）환자성격소수평적영향，탐토소요산치료슬OA적가능작용궤제。방법선취아원골과문진녀성슬OA환자60례，수궤분위중약조、서의조각30례。중약조복용소요환9주、서약조복용류산안기포도당효낭9주，치료전、후여체검중심선택적30례50~65세무슬관절증상적녀성체검인원균공복추혈검측자이순、고환동함량，수거경통계학처리。결과슬OA조환자년령교정상조소，혈청자이순함량교정상조저；중약조치료후혈청자이순함량명현승고，병명현고우서약조(P>0.05)。결론소요산통과영향중노년녀성자이순함량변화가능위슬OA환자적치료제공일충경이상적선택。
Objective To explore the influence of sex hormone levels with Xiaoyaosan to menopausal women Knee Osteoarthritis(Short for Knee OA) and approach the mechanism.Method Choose 60 female patients with knee OA.Randomly divided into 2 small groups: Chinese-Medicine group and Western-Medicine group, 30 females for each small group. The patients in Chinese-Medicine group takes Xiaoyaosan pill and Glucosamine Sulfate Capsules for the patients in Western-Medicine group, 9 weeks a period. Then 30 females without symptoms of knee OA from the physical examination center as normal group, all patients were fasting blood tested with female hormone and testosterone level before and after treatment, data were statistically processed.Results The average age of patients in Knee-OA group is smaller than the normal group, however, the female hormone level for Knee-OA Group is lower than normal group, to compare with Chinese-Medicine group and Western-Medicine group, the female hormone level for Chinese-Medicine group is much more higher than Western-Medicine group, statistically signiifcant difference (P<0.05).ConclusionXiaoyaosan could change the content of estradiol for menopausal women, it may provide a better choice for the treatment of patients with knee OA.