CAJ | 학술논문

目的：探讨Yes相关蛋白（YAP）在口腔鳞状细胞癌中的表达情况及其与p53表达的关系。方法采用免疫组织化学法对29例高分化、19例中分化、12例低分化口腔鳞状细胞癌组织及10例正常口腔黏膜组织的YAP及p53蛋白表达情况进行检测。结果与正常口腔黏膜组织（20.0％）相比，YAP在口腔鳞状细胞癌（83.3％）中的表达明显增高，差异有统计学意义（P＜0.05）。YAP的表达与口腔鳞状细胞癌的年龄、性别、发病部位、淋巴结转移等临床病理特征无关（P＞0.05）。p53在口腔鳞状细胞癌组织中阳性率为71.7％（43/60）。口腔鳞癌中YAP与p53的表达呈正相关（r=0.343，P＜0.05）。结论 YAP在口腔鳞状细胞癌中表达明显增高，且与p53表达相关，二者共同参与口腔鳞状细胞癌的发生、发展。
목적：탐토Yes상관단백（YAP）재구강린상세포암중적표체정황급기여p53표체적관계。방법채용면역조직화학법대29례고분화、19례중분화、12례저분화구강린상세포암조직급10례정상구강점막조직적YAP급p53단백표체정황진행검측。결과여정상구강점막조직（20.0％）상비，YAP재구강린상세포암（83.3％）중적표체명현증고，차이유통계학의의（P＜0.05）。YAP적표체여구강린상세포암적년령、성별、발병부위、림파결전이등림상병리특정무관（P＞0.05）。p53재구강린상세포암조직중양성솔위71.7％（43/60）。구강린암중YAP여p53적표체정정상관（r=0.343，P＜0.05）。결론 YAP재구강린상세포암중표체명현증고，차여p53표체상관，이자공동삼여구강린상세포암적발생、발전。
Objective To investigate the expression of Yes-associated protein (YAP) in oral squamous cell car-cinoma (OSCC) and its correlation with p53 expression. Methods Using immunohistochemistry to determine the YAP and p53 protein expression in 29 high differentiated, 19 moderate differentiated, and 12 low differentiated OSCC tis-sues and 10 normal oral mucosa tissues. Results YAP expression was significantly increased in OSCC (83.3%), which was higher than that in the normal oral mucosa (20.0%), with statistically significant difference ( P<0.05). There were no differences between the YAP expression and the clinical and pathological characteristics of OSCC, including age, gender, disease location, lymph node metastasis (P>0.05). The positive rate of p53 in OSCC tissues was 71.7%(43/60). The expression of YAP and p53 was positively correlated in OSCC (r=0.343, P<0.05). Conclusion YAP ex-pression is significantly increased in OCSS and correlated with p53 expression. Both of YAP and p53 participate in the occurrence and development of OSCC.