CAJ | 학술논문

对铂类抗肿瘤药物米铂的热稳定性和晶型进行了分析与研究.通过热分析（DSC-TG）法测定药物的熔点及结晶水的含量，并结合X射线粉末衍射仪（XPRD）及其原位高温（in-situ high temperature）附件测定了样品米铂的晶型结构及在加热过程中的晶型热稳定性.结果表明，试样米铂含有一个结晶水，加热到51.64℃时开始失去结晶水，在74.18℃发生微小的晶相转变，从亚稳态晶型转变为稳态晶型，210℃时转变为非晶态，221.81℃发生熔融变化，开始分解.
대박류항종류약물미박적열은정성화정형진행료분석여연구.통과열분석（DSC-TG）법측정약물적용점급결정수적함량，병결합X사선분말연사의（XPRD）급기원위고온（in-situ high temperature）부건측정료양품미박적정형결구급재가열과정중적정형열은정성.결과표명，시양미박함유일개결정수，가열도51.64℃시개시실거결정수，재74.18℃발생미소적정상전변，종아은태정형전변위은태정형，210℃시전변위비정태，221.81℃발생용융변화，개시분해.
The purpose of this study is to investigate the thermostability and the crystal structure of a novel antitumor drug miriplatin. The thermostability of miriplatin was analyzed using thermal analysis(DSC-TG),and crystal structure was determined using the X-ray powder diffraction(XPRD)with in-situ high temperature accessories. The results showed that miriplatin contains one mole water of crystallization. When heated to 51.64℃,miriplatin would lose the wa?ter of crystallization. And a slight polymorphic phase transition happened at 74.18 ℃,from metastable state to stable state. Miriplatin would transform into amorphous phase at 210℃,and fuse at 221.81℃. This study provides a compre?hensive reference for the quality evaluation of miriplatin.