中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
9期
82-84
,共3页
肝切除术%七氟烷%丙泊酚%炎症因子%肝功能
肝切除術%七氟烷%丙泊酚%炎癥因子%肝功能
간절제술%칠불완%병박분%염증인자%간공능
hepatectomy%sevoflurane%propofol%inflammatory cytokines%liver function
目的:探讨丙泊酚和七氟烷麻醉对肝切除术患者术后炎症因子和肝脏功能的影响。方法选取40例肝切除术患者,随机分为丙泊酚组(P组)、七氟烷组(S组),每组20例。 P组和S组分别丙泊酚靶控注射或吸入七氟醚维持麻醉。比较2组患者手术前后丙氨酸氨基转移酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBil)、天门冬氨酸氨基转移酶(aspartate amino transferase,AST)、白蛋白(albumin,ALB)及血浆肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白介素-6(interleukin-6,IL-6)、白介素-10(interleukin-10,IL-10)水平。统计2组患者并发症发生率。结果术后1、3、7 d,S组AST、ALT、TBiL水平显著低于P组( P<0.05),但2组ALB水平差异无统计学意义,S组血浆TNF-α、IL-6及IL-10显著低于P组(P<0.05)。 S组术后发生并发症的患者为6(30.0%)例,与P组的10(20.0%)例比较差异无统计学意义(χ2=1.67,P>0.05)。结论七氟烷吸入可有效抑制肝切除术后血浆炎症因子分泌,促进肝功能恢复,其效果优于丙泊酚。
目的:探討丙泊酚和七氟烷痳醉對肝切除術患者術後炎癥因子和肝髒功能的影響。方法選取40例肝切除術患者,隨機分為丙泊酚組(P組)、七氟烷組(S組),每組20例。 P組和S組分彆丙泊酚靶控註射或吸入七氟醚維持痳醉。比較2組患者手術前後丙氨痠氨基轉移酶(alanine aminotransferase,ALT)、總膽紅素(total bilirubin,TBil)、天門鼕氨痠氨基轉移酶(aspartate amino transferase,AST)、白蛋白(albumin,ALB)及血漿腫瘤壞死因子-α(tumor necrosis factor,TNF-α)、白介素-6(interleukin-6,IL-6)、白介素-10(interleukin-10,IL-10)水平。統計2組患者併髮癥髮生率。結果術後1、3、7 d,S組AST、ALT、TBiL水平顯著低于P組( P<0.05),但2組ALB水平差異無統計學意義,S組血漿TNF-α、IL-6及IL-10顯著低于P組(P<0.05)。 S組術後髮生併髮癥的患者為6(30.0%)例,與P組的10(20.0%)例比較差異無統計學意義(χ2=1.67,P>0.05)。結論七氟烷吸入可有效抑製肝切除術後血漿炎癥因子分泌,促進肝功能恢複,其效果優于丙泊酚。
목적:탐토병박분화칠불완마취대간절제술환자술후염증인자화간장공능적영향。방법선취40례간절제술환자,수궤분위병박분조(P조)、칠불완조(S조),매조20례。 P조화S조분별병박분파공주사혹흡입칠불미유지마취。비교2조환자수술전후병안산안기전이매(alanine aminotransferase,ALT)、총담홍소(total bilirubin,TBil)、천문동안산안기전이매(aspartate amino transferase,AST)、백단백(albumin,ALB)급혈장종류배사인자-α(tumor necrosis factor,TNF-α)、백개소-6(interleukin-6,IL-6)、백개소-10(interleukin-10,IL-10)수평。통계2조환자병발증발생솔。결과술후1、3、7 d,S조AST、ALT、TBiL수평현저저우P조( P<0.05),단2조ALB수평차이무통계학의의,S조혈장TNF-α、IL-6급IL-10현저저우P조(P<0.05)。 S조술후발생병발증적환자위6(30.0%)례,여P조적10(20.0%)례비교차이무통계학의의(χ2=1.67,P>0.05)。결론칠불완흡입가유효억제간절제술후혈장염증인자분비,촉진간공능회복,기효과우우병박분。
Objective To evaluate efficacy of propofol compared with sevoflurane on inflammatory factor and liver function after hepatectomy. Methods 40 cases with hepatectomy were divided into propofol group ( P group) and sevoflurane group ( S group) , 20 cases in each group.The P group and S group respectively were given propofol or sevoflurane maintained anesthesia.The alanine aminotransferase( ALT) , total bilirubin( TBil) , aspartate amino transferase(AST), albumin(ALB), plasma tumor necrosis factor(TNF-α), interleukin-6(IL-6), interleukin-10(IL-10)and complication rate were compared between two groups.Results Postoperation 1d, 3d and 7d, the AST, ALT, and TBiL levels of S group were significantly lower than those of P group (P<0.05).There was no significant difference of ALB level between two groups.The plasma TNF-α, IL-6 and IL-10 levels of S group were significantly lower than those of P group (P<0.05).There was no significant differece of the rate of postoperative complications between S group and P group [6(30.0%) vs.10 (20.0%); χ2 =1.67, P >0.05].Conclusion Sevoflurane inhalation could effectively inhibit the plasma inflammatory cytokines secretion after hepatectomy, and promote liver function recovery, its effect is better than that of propofol.