CAJ | 학술논문

目的：探讨不同镇痛方案对乳腺癌患者手术后免疫状况与血清炎性因子的影响。方法收集天津医科大学肿瘤医院救治欲行乳腺根治术的乳腺癌患者60例。随机将所选患者分为实验组及对照组。围手术期实验组与对照组患者分别使用地佐辛与芬太尼镇痛，对2组患者的免疫状况及血清炎性因子进行分析与对比。结果术毕及术后1d实验组患者的外周T淋巴细胞亚群（CD3＋、CD4＋的水平及CD4＋／CD8＋比值）与NK细胞的水平均明显高于对照组（P＜0.05）；术毕及术后1d实验组患者血清中的抗炎因子明显高于对照组（ P＜0.05）；术毕及术后1d实验组患者血清中的促炎因子明显低对照组（ P＜0.05）。结论地佐辛能明显改善手术后乳腺癌患者血清中的炎性因子，调节患者的免疫状况。
목적：탐토불동진통방안대유선암환자수술후면역상황여혈청염성인자적영향。방법수집천진의과대학종류의원구치욕행유선근치술적유선암환자60례。수궤장소선환자분위실험조급대조조。위수술기실험조여대조조환자분별사용지좌신여분태니진통，대2조환자적면역상황급혈청염성인자진행분석여대비。결과술필급술후1d실험조환자적외주T림파세포아군（CD3＋、CD4＋적수평급CD4＋／CD8＋비치）여NK세포적수평균명현고우대조조（P＜0.05）；술필급술후1d실험조환자혈청중적항염인자명현고우대조조（ P＜0.05）；술필급술후1d실험조환자혈청중적촉염인자명현저대조조（ P＜0.05）。결론지좌신능명현개선수술후유선암환자혈청중적염성인자，조절환자적면역상황。
Objective To discuss comparison of different analgesic solution to the immune status and serum levels of inflammatory cytokines of the patients with breast cancer after surgery.Methods The patients of experimental group and control group were given Dizocine and fentanyl to analgesic respectively perioperative experimental.Then analysis and comparison the immune status and serum levels of the two groups.Results The T lymphocyte subsets ( The level of CD3 +、CD4 +and the ratio CD4 +/CD8 +) and the level fo NK cells of the exprimental group patients intraoperative and postoperative 1 d were significantly higer than the control group.The anti-inflammatory factor in the serum of the experimental group patients intraoperative and postoperative 1d was significantly higer than the control group.The proinflammatory factor in the serum of the experimental group patients intraoperative and postoperative 1 d was significantly lower than the control group.Conclusion Dizocine can significantly improve the serum inflammatory factors of the patients with brest cancer after surgery,and can adjust the patient’s immune status.