CAJ | 학술논문

背景：血管纵向方面的拉伸力学特性、径向方面必要的血管张力，是组织灌注和压力维持的重要保证。目的：通过拉伸、穿刺指标的测试和分析表征血管性能，侧面地预测移植入受体后血管的健康状况。<br>　　方法：采用猪主动脉血管为材料，利用动态力学分析仪对血管周向拉伸、轴向拉伸及穿刺方面的力学性能进行了测试实验，并结合切片及染色分析，分析冻干后的血管移植入体内后，能否承受血液对其造成的各个方向的压力。<br>　　结果与结论：冻干后血管的周向拉伸、轴向拉伸及穿刺过程曲线都分别与新鲜血管该段过程曲线的趋势比较接近，说明血管在冻干后结构成分及排列方式没有发生大的改变；同时结合切片及拉伸断面的显微观察，研究和解释了各项力学性能实验数据和结果出现的原因，利用微观结构的变化分析了宏观力学的实验结果。结果说明真空冷冻干燥的方法能够较好地保持血管力学方面的各项性能。
배경：혈관종향방면적랍신역학특성、경향방면필요적혈관장력，시조직관주화압력유지적중요보증。목적：통과랍신、천자지표적측시화분석표정혈관성능，측면지예측이식입수체후혈관적건강상황。<br>　　방법：채용저주동맥혈관위재료，이용동태역학분석의대혈관주향랍신、축향랍신급천자방면적역학성능진행료측시실험，병결합절편급염색분석，분석동간후적혈관이식입체내후，능부승수혈액대기조성적각개방향적압력。<br>　　결과여결론：동간후혈관적주향랍신、축향랍신급천자과정곡선도분별여신선혈관해단과정곡선적추세비교접근，설명혈관재동간후결구성분급배렬방식몰유발생대적개변；동시결합절편급랍신단면적현미관찰，연구화해석료각항역학성능실험수거화결과출현적원인，이용미관결구적변화분석료굉관역학적실험결과。결과설명진공냉동간조적방법능구교호지보지혈관역학방면적각항성능。
BACKGROUND:Mechanical properties of the blood vessels include axial and radial tension which is important to guarantee the tissue perfusion and its pressure. OBJECTIVE:To test and analyze stretching and puncture parameters that can ful y characterize the performance of blood vessels, so as to predict the health condition of the vessels transplanted into recipients. METHODS:Mechanical properties as circumferential tension, axial tension and puncture were tested on the porcine aorta, and then pathological and staining analysis was done to explore whether freeze-dried vessels can withstand the blood pressure in al directions after transplanted into the body. RESULTS AND CONCLUSION:Specific trend on the curves of freeze-dried vessels during circumferential tension, axial tension and puncture process was closer to that of fresh vessel curves, suggesting that structural components and arrangement of the freeze-dried vessels were not changed greatly. Meanwhile, the microscopic observations of slice and tensile section were taken into account so that the reason was studied and explained for the mechanical properties of the experimental data and results. The macroscopic mechanical result was analyzed based on the change of microstructure. These findings indicate that the vacuum freeze-drying is a better method to maintain the performance of blood vessels.