临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
11期
2080-2082
,共3页
肺表面活性物质%新生儿%胎粪吸入综合征%呼吸窘迫综合征
肺錶麵活性物質%新生兒%胎糞吸入綜閤徵%呼吸窘迫綜閤徵
폐표면활성물질%신생인%태분흡입종합정%호흡군박종합정
pulmonary surfactant%newborn%meconium aspiration syndrome%respiratory distress syndrome
目的：探讨肺表面活性物质( PS)治疗新生儿胎粪吸入综合征( MAS)和新生儿呼吸窘迫综合征( NRDS)的临床疗效及安全性。方法选择MAS患儿58例( MAS组)和NRDS患儿42例( NRDS组)为研究对象,两组患者均在常规治疗的基础上给予PS治疗,治疗结束24h后比较MAS组和NRDS组患者的动脉氧分压( PaO2)、二氧化碳分压( PaCO2)、氧合指数( OI)、治愈情况和并发症情况。结果治疗前两组患儿的PaO2、PaCO2、OI组间比较差异均无明显的统计学意义(P>0．05)；治疗后24 h两组患儿的PaO2、PaCO2、OI组间比较差异均无明显的统计学意义(P>0．05)；MAS患儿治愈率100%,NRDS患儿治愈率97．62%,组间比较差异无明显的统计学意义(P>0．05)；MAS组并发症发生率为24．14%,NRDS组并发症发生率28．57%,组间比较差异无明显的统计学意义(P大于0．05)；患儿的PaO2、PaCO2、OI治疗前后组内比较差异有明显的统计学意义(P<0．05)。结论 PS治疗新生儿MAS和NRDS均能够获得满意效果,患儿的PaO2、PaCO2、OI指标能得到明显改善。
目的：探討肺錶麵活性物質( PS)治療新生兒胎糞吸入綜閤徵( MAS)和新生兒呼吸窘迫綜閤徵( NRDS)的臨床療效及安全性。方法選擇MAS患兒58例( MAS組)和NRDS患兒42例( NRDS組)為研究對象,兩組患者均在常規治療的基礎上給予PS治療,治療結束24h後比較MAS組和NRDS組患者的動脈氧分壓( PaO2)、二氧化碳分壓( PaCO2)、氧閤指數( OI)、治愈情況和併髮癥情況。結果治療前兩組患兒的PaO2、PaCO2、OI組間比較差異均無明顯的統計學意義(P>0．05)；治療後24 h兩組患兒的PaO2、PaCO2、OI組間比較差異均無明顯的統計學意義(P>0．05)；MAS患兒治愈率100%,NRDS患兒治愈率97．62%,組間比較差異無明顯的統計學意義(P>0．05)；MAS組併髮癥髮生率為24．14%,NRDS組併髮癥髮生率28．57%,組間比較差異無明顯的統計學意義(P大于0．05)；患兒的PaO2、PaCO2、OI治療前後組內比較差異有明顯的統計學意義(P<0．05)。結論 PS治療新生兒MAS和NRDS均能夠穫得滿意效果,患兒的PaO2、PaCO2、OI指標能得到明顯改善。
목적：탐토폐표면활성물질( PS)치료신생인태분흡입종합정( MAS)화신생인호흡군박종합정( NRDS)적림상료효급안전성。방법선택MAS환인58례( MAS조)화NRDS환인42례( NRDS조)위연구대상,량조환자균재상규치료적기출상급여PS치료,치료결속24h후비교MAS조화NRDS조환자적동맥양분압( PaO2)、이양화탄분압( PaCO2)、양합지수( OI)、치유정황화병발증정황。결과치료전량조환인적PaO2、PaCO2、OI조간비교차이균무명현적통계학의의(P>0．05)；치료후24 h량조환인적PaO2、PaCO2、OI조간비교차이균무명현적통계학의의(P>0．05)；MAS환인치유솔100%,NRDS환인치유솔97．62%,조간비교차이무명현적통계학의의(P>0．05)；MAS조병발증발생솔위24．14%,NRDS조병발증발생솔28．57%,조간비교차이무명현적통계학의의(P대우0．05)；환인적PaO2、PaCO2、OI치료전후조내비교차이유명현적통계학의의(P<0．05)。결론 PS치료신생인MAS화NRDS균능구획득만의효과,환인적PaO2、PaCO2、OI지표능득도명현개선。
Objective To explore the curative effect and safety of lung surface active substances ( PS) in the treatment of neonatal meconium inhaled syndrome ( MAS ) and neonatal respiratory distress syndrome ( NRDS ) . Methods The study selected 58 children with MAS and 42 children with NRDS. All children were given convention-al therapy and PS treatment. 24 hours after the treatment, their arterial oxygen partial pressure ( PaO2 ) , CO2 partial pressure ( PaCO2 ) , oxygen index ( OI) , curative effect and complications were compared between the two groups. Results The level of PaO2 , PaCO2 and OI had no significant difference between the two groups before treatment ( P>0. 05), and it still showed no significant differences 24 hour after the treatment between the two groups (P >0. 05). The curative rate of MAS was 100%, and 97. 62% of NRDS (P>0. 05). The incidence of complications was 24. 14% in the MAS group, and 28. 57% in the NRDS group (P>0. 05). The level of PaO2, PaCO2 and OI showed significant statistical significance before and after the treatment in the same group (P<0. 05). Conclusion PS treatment has satisfying curative effect in the treatment of neonatal MAS and NRDS, which can significant improve the indexes of PaO2 , PaCO2 and OI.
