中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
9期
70-72
,共3页
张勇%侯静%王凌云%那振琦%李越%张允岭
張勇%侯靜%王凌雲%那振琦%李越%張允嶺
장용%후정%왕릉운%나진기%리월%장윤령
血栓通注射液%急性脑梗死%炎性因子%同型半胱氨酸
血栓通註射液%急性腦梗死%炎性因子%同型半胱氨痠
혈전통주사액%급성뇌경사%염성인자%동형반광안산
Xueshuantong injection%acute cerebral infarction%inflammatory factors%homocysteine
目的：探讨血栓通注射液治疗急性脑梗死的临床疗效及对患者炎性因子与同型半胱氨酸（ homocysteine，Hcy）水平的影响。方法回顾分析2014年1月～2015年5月于解放军第三一三医院接受治疗的128例急性脑梗死患者资料，按照治疗方案分为对照组（n＝62）和观察组（n＝66）。对照组给予抗血小板聚集、调脂、维持水电解质、酸碱平衡、控制血糖、血压等常规治疗，观察组在对照组基础上给予血栓通注射液治疗。2周疗程结束后，观察比较2组患者临床疗效，炎性因子如超敏C反应蛋白（ high-sensitivity C reactive protein，hs-CRP）、肿瘤坏死因子α（tumor necrosis factorα，TNF-α）、白细胞介素8（interleukin 8，IL-8），Hcy水平及不良反应发生情况。结果观察组总有效率为93.9％，显著高于对照组的80.6％（χ2＝5.166， P＝0.023）。与对照组相比，观察组治疗后hs-CRP、TNF-α、IL-8水平显著下降（均P＜0.05）。治疗后1、2周，观察组Hcy水平均较对照组显著降低（均P＜0.05）。观察组不良反应发生为8例（12.1％），对照组6例（9.7％），2组间比较差异无统计学意义（χ2＝0.196，P＝0.658）。结论血栓通注射液治疗急性脑梗死疗效可靠，能够显著提高临床疗效，减轻机体炎性反应，降低Hcy水平，且不良反应少。
目的：探討血栓通註射液治療急性腦梗死的臨床療效及對患者炎性因子與同型半胱氨痠（ homocysteine，Hcy）水平的影響。方法迴顧分析2014年1月～2015年5月于解放軍第三一三醫院接受治療的128例急性腦梗死患者資料，按照治療方案分為對照組（n＝62）和觀察組（n＝66）。對照組給予抗血小闆聚集、調脂、維持水電解質、痠堿平衡、控製血糖、血壓等常規治療，觀察組在對照組基礎上給予血栓通註射液治療。2週療程結束後，觀察比較2組患者臨床療效，炎性因子如超敏C反應蛋白（ high-sensitivity C reactive protein，hs-CRP）、腫瘤壞死因子α（tumor necrosis factorα，TNF-α）、白細胞介素8（interleukin 8，IL-8），Hcy水平及不良反應髮生情況。結果觀察組總有效率為93.9％，顯著高于對照組的80.6％（χ2＝5.166， P＝0.023）。與對照組相比，觀察組治療後hs-CRP、TNF-α、IL-8水平顯著下降（均P＜0.05）。治療後1、2週，觀察組Hcy水平均較對照組顯著降低（均P＜0.05）。觀察組不良反應髮生為8例（12.1％），對照組6例（9.7％），2組間比較差異無統計學意義（χ2＝0.196，P＝0.658）。結論血栓通註射液治療急性腦梗死療效可靠，能夠顯著提高臨床療效，減輕機體炎性反應，降低Hcy水平，且不良反應少。
목적：탐토혈전통주사액치료급성뇌경사적림상료효급대환자염성인자여동형반광안산（ homocysteine，Hcy）수평적영향。방법회고분석2014년1월～2015년5월우해방군제삼일삼의원접수치료적128례급성뇌경사환자자료，안조치료방안분위대조조（n＝62）화관찰조（n＝66）。대조조급여항혈소판취집、조지、유지수전해질、산감평형、공제혈당、혈압등상규치료，관찰조재대조조기출상급여혈전통주사액치료。2주료정결속후，관찰비교2조환자림상료효，염성인자여초민C반응단백（ high-sensitivity C reactive protein，hs-CRP）、종류배사인자α（tumor necrosis factorα，TNF-α）、백세포개소8（interleukin 8，IL-8），Hcy수평급불량반응발생정황。결과관찰조총유효솔위93.9％，현저고우대조조적80.6％（χ2＝5.166， P＝0.023）。여대조조상비，관찰조치료후hs-CRP、TNF-α、IL-8수평현저하강（균P＜0.05）。치료후1、2주，관찰조Hcy수평균교대조조현저강저（균P＜0.05）。관찰조불량반응발생위8례（12.1％），대조조6례（9.7％），2조간비교차이무통계학의의（χ2＝0.196，P＝0.658）。결론혈전통주사액치료급성뇌경사료효가고，능구현저제고림상료효，감경궤체염성반응，강저Hcy수평，차불량반응소。
Objective To investigate the effects of Xueshuantong injection on levels of inflammatory factors and homocysteine (Hcy) in patients with acute cerebral infarction.Methods 128 patients of acute cerebral infarction who received therapy in the hospital from January 2014 to May 2015 were collected as research objects to retrospectively analyze their clinical materials.According to therapeutic schemes, those patients were divided into control group (n=62) and observation group (n=66).The control group were given conventional treatments, such as anti-platelet aggregation, lipid regulation, maintaining balance of water-electrolyte and acid-base, controlling blood glucose, controlling blood pressure and so on.Besides that, the observation group were given Xueshuantong injection.After two weeks treatment, the curative efficacy, levels of inflammatory factors as high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor α(TNF-α), interleukin 8 (IL-8), Hcy and adverse reactions were compared.Results The total efficacy of observation group was 93.9%, which was statistically higher than that of 80.6%in control group (χ2 =5.166,P=0.023).After treatment, hs-CRP, TNF-α, IL-8 levels in observation group were significantly lower than those in control group (all P<0.05).After one and two weeks treatment, The Hcy level in observation group was statistically lower than that in control group ( all P<0.05 ).The adverse reactions in observation group was 8 cases ( 12.1%), 6 cases ( 9.7%) in control group, with no significant difference between two groups (χ2 =0.196, P =0.658 ). Conclusion Xueshuantong injection is effective in treatment of acute cerebral infarction, which could significantly increase curative efficacy, alleviate inflammatory reaction and reduce level of Hcy with less adverse reactions.
