CAJ | 학술논문

目的：探讨博尔纳病病毒（ Borna disease virus， BDV）感染与遵义地区多发性硬化（ multiple sclerosis，MS）患者的相关性。方法运用新型的三联ELISA测循环免疫复合物、抗体的方法，检测7例MS患者及93例健康对照组血清中BDV特异性循环免疫复合物（circulating immune complex，CIC）及抗体。结果7例MS中有2例CIC及抗体均为阳性，阳性率为28.57％（2／7）；93例对照组中CIC阳性7人，阳性率为7.53％（7／93），抗体阳性5例，阳性率为5.38％（5／93）；多发性硬化组检出率高于健康对照对照组，但2组比较无统计学意义。结论遵义地区存在着BDV的感染，BDV感染与多发性硬化不一定相关。
목적：탐토박이납병병독（ Borna disease virus， BDV）감염여준의지구다발성경화（ multiple sclerosis，MS）환자적상관성。방법운용신형적삼련ELISA측순배면역복합물、항체적방법，검측7례MS환자급93례건강대조조혈청중BDV특이성순배면역복합물（circulating immune complex，CIC）급항체。결과7례MS중유2례CIC급항체균위양성，양성솔위28.57％（2／7）；93례대조조중CIC양성7인，양성솔위7.53％（7／93），항체양성5례，양성솔위5.38％（5／93）；다발성경화조검출솔고우건강대조대조조，단2조비교무통계학의의。결론준의지구존재착BDV적감염，BDV감염여다발성경화불일정상관。
Objective To study the correlation with the infectious situation of Borna disease with the multiple sclerosisof Zunyi region. Methods Established method of the specific CIC and an antibody of Borna were used to detect the PBMC of 7cases of patients with multiple sclerosis and 93 cases of control group.Results In the collected 7 cases of PBMC in patients with multiple sclerosis, detected 2 positive samples of the specific CIC and antibody of Borna with a positive rate of 28.57%(2/7).Meanwhile, positive plasma samples were also detected in healthy control group, and the positive rate was 7.53%(7/93),The antibody positive rate of control group was also 5.38%(5/93).But between the two groups, the difference was no statistically significant.Conclusion Results indicate that the possibility of BDV infection is presented in Zunyi regions.BDV infection is not necessarily associated with multiple sclerosis.