CAJ | 학술논문

目的：探讨舒血宁联合磷酸肌酸钠对急性一氧化碳中毒（ACOP）患者缺血修饰白蛋白（IMA）水平的影响及临床疗效比较。方法选择ACOP患者86例随机分为常规组及治疗组，所有入选者治疗前，治疗后6 h、3 d分别抽取静脉血检测肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、肌钙蛋白I（cTnI）、IMA水平。结果治疗前IMA均显著降低，而CK、CK-MB、cTnI无明显改变。治疗后6 h，治疗组IMA升高较常规组明显，差异有统计学意义（P＜0.05）。CK、CK-MB、cTnI逐渐升高，2组比较差异无统计学意义（P＞0.05）。治疗后3 d，常规组cTnI水平较治疗组升高明显，2组比较差异有统计学意义（P＜0.05）。常规组与治疗组比较，CK、CK-MB、IMA均恢复正常水平，2组比较差异无统计学意义（P＞0.05）。治疗后3 d cTnI水平与治疗后6 h水平比较明显好转，差异有统计学意义（P＜0.05）。结论 ACOP患者早期给予舒血宁联合磷酸肌酸钠治疗，IMA水平明显升高，中毒性心肌损伤明显恢复。IMA水平可作为心肌缺血及药物治疗的评价指标。
목적：탐토서혈저연합린산기산납대급성일양화탄중독（ACOP）환자결혈수식백단백（IMA）수평적영향급림상료효비교。방법선택ACOP환자86례수궤분위상규조급치료조，소유입선자치료전，치료후6 h、3 d분별추취정맥혈검측기산격매（CK）、기산격매동공매（CK-MB）、기개단백I（cTnI）、IMA수평。결과치료전IMA균현저강저，이CK、CK-MB、cTnI무명현개변。치료후6 h，치료조IMA승고교상규조명현，차이유통계학의의（P＜0.05）。CK、CK-MB、cTnI축점승고，2조비교차이무통계학의의（P＞0.05）。치료후3 d，상규조cTnI수평교치료조승고명현，2조비교차이유통계학의의（P＜0.05）。상규조여치료조비교，CK、CK-MB、IMA균회복정상수평，2조비교차이무통계학의의（P＞0.05）。치료후3 d cTnI수평여치료후6 h수평비교명현호전，차이유통계학의의（P＜0.05）。결론 ACOP환자조기급여서혈저연합린산기산납치료，IMA수평명현승고，중독성심기손상명현회복。IMA수평가작위심기결혈급약물치료적평개지표。
Objective To investigate the effect of Ginkgo Biloba leaf extract and creatine phosphate sodium on ischemia modified albumin (IMA) level in patients with acute carbon monoxide poisoning (ACOP), and to compare the clinical efficacy before and after the treatment. Methods Eighty-six patients with ACOP were included as the sub-jects in the study, and were randomly divided into the conventional group and the treatment group. The CK, CK-MB, cTnI, and IMA levels in venous blood of all subjects were determined at 6 h and 3 d before and after the treatment, respectively. Results IMA was significantly decreased before the treatment, whereas no significant changes were found on CK, CK-MB and cTnI levels. At 6 h after the treatment, IMA was significantly increased in the treatment group compared with that in the conventional group, with statistically significant difference ( P<0.05);whereas CK, CK-MB and cTnI levels increased gradually, without differences between the conventional group and the treatment group (P>0.05). At 3 d after the treatment, cTnI level was significantly increased in the conventional group compared with that in the treatment group, with significant difference between the two groups ( P<0.05). CK, CK-MB and IMA levels all returned to normal and there were no differences between the conventional group and the treatment group ( P>0.05). The cTnI level was significantly improved at 3 d after the treatment compared with that at 6 h after the treatment ( P<0.05). Conclusion IMA level is significantly increased and poisoning induced myocardial injury is significantly re covered in ACOP patients received early treatment with Ginkgo Biloba leaf extract and creatine phosphate sodium. IMA level can be used as evaluation index of myocardial ischemia and drug treatment.