中国体外循环杂志
中國體外循環雜誌
중국체외순배잡지
Chinese Journal of Extracorporeal Circulation
2015年
3期
174-177
,共4页
翟蒙恩%李步潆%段维勋%杨阳%罗礼阳%于立明%刘宝辉%梁宏亮%金振晓%俞世强
翟矇恩%李步瀠%段維勛%楊暘%囉禮暘%于立明%劉寶輝%樑宏亮%金振曉%俞世彊
적몽은%리보형%단유훈%양양%라례양%우립명%류보휘%량굉량%금진효%유세강
心肌肥厚%主动脉缩窄术%开胸手术%微创手术
心肌肥厚%主動脈縮窄術%開胸手術%微創手術
심기비후%주동맥축착술%개흉수술%미창수술
Cardiac hypertrophy%Transverse aortic constriction%Thoracotomy%Minimally invasive surgery
目的:比较改良小鼠主动脉弓缩窄( TAC)模型与经典模型的优缺点并详细介绍改良方式。方法将C57BL/6小鼠随机分为四组:经典Sham组( Sham-C)、经典TAC组( TAC-C)、改良Sham组( Sham-N)和改良TAC组( TAC-N),比较手术时间、术中及术后4周小鼠生存率等指标。术后4周超声心动图检测心功能,心体比、心胫骨比、心脏HE染色用于反映心肌肥大程度。结果 TAC-C组手术时间为(24.88±2.99)min,而TAC-N组只需(6.90±0.63)min;TAC-C组术中死亡1例,术后4周死亡2例,生存率80%,而TAC-N组术中死亡1例,术后无死亡,生存率为93.3%;超声检查、大体指标及HE染色均显示两种模型术后4周心肌肥厚程度无明显差异。结论小鼠改良微创TAC术构建心肌肥厚模型,安全、耗时短、重复性好、成功率高。
目的:比較改良小鼠主動脈弓縮窄( TAC)模型與經典模型的優缺點併詳細介紹改良方式。方法將C57BL/6小鼠隨機分為四組:經典Sham組( Sham-C)、經典TAC組( TAC-C)、改良Sham組( Sham-N)和改良TAC組( TAC-N),比較手術時間、術中及術後4週小鼠生存率等指標。術後4週超聲心動圖檢測心功能,心體比、心脛骨比、心髒HE染色用于反映心肌肥大程度。結果 TAC-C組手術時間為(24.88±2.99)min,而TAC-N組隻需(6.90±0.63)min;TAC-C組術中死亡1例,術後4週死亡2例,生存率80%,而TAC-N組術中死亡1例,術後無死亡,生存率為93.3%;超聲檢查、大體指標及HE染色均顯示兩種模型術後4週心肌肥厚程度無明顯差異。結論小鼠改良微創TAC術構建心肌肥厚模型,安全、耗時短、重複性好、成功率高。
목적:비교개량소서주동맥궁축착( TAC)모형여경전모형적우결점병상세개소개량방식。방법장C57BL/6소서수궤분위사조:경전Sham조( Sham-C)、경전TAC조( TAC-C)、개량Sham조( Sham-N)화개량TAC조( TAC-N),비교수술시간、술중급술후4주소서생존솔등지표。술후4주초성심동도검측심공능,심체비、심경골비、심장HE염색용우반영심기비대정도。결과 TAC-C조수술시간위(24.88±2.99)min,이TAC-N조지수(6.90±0.63)min;TAC-C조술중사망1례,술후4주사망2례,생존솔80%,이TAC-N조술중사망1례,술후무사망,생존솔위93.3%;초성검사、대체지표급HE염색균현시량충모형술후4주심기비후정도무명현차이。결론소서개량미창TAC술구건심기비후모형,안전、모시단、중복성호、성공솔고。
Objective To comprehensively and technically introduce a novel transverse aortic constriction( TAC) surgery mod?el in mice and compare this relatively less invasive surgical modelto the classic TAC model. Methods C57BL/6 mice were divided in?to four groups:Sham-Classic;TAC-Classic;Sham-Novel;TAC-Novel. Mean operating time and overall survival rate during operating time and at week-4 were measured. Echocardiography was used to determine cardiac function. HW/BW, HW/TL and HE staining were used to measure the degree of cardiac hypertrophy. Results The average operating time using classic TAC surgery is 24.88±2.99 min, while TAC-N requires only 6.90±0.63 min ( P<0.01). The survival rate is 80% (TAC-C) vs 93.3% (TAC-N). No significant difference was shown in echocardiograph, HE staining, HW/BW and HW/TL between these two models. Conclusion This new ap?proach is more efficient and safer for mice while not compromising the extent of cardiac hypertrophy.