CAJ | 학술논문

1实验建立了稳定的甲亢兔不同左室构型的心脏损害模型，并应用分子生物学方法研究甲亢兔不同左室构型的B型脑钠肽变化及心功能的变化，找出不同左室构型的甲亢兔血浆B型脑钠肽与其心功能相关性以及与超声各指标变化的相关性。<br>　　2实验的特点在于应用超声新技术对甲亢兔不同左室构型的心脏损害，并对照病理结果结合血液生化因子检测进行诊断的常规参数的筛选。应用超声新技术及常规超声对甲亢患者的心脏结构及功能进行评价，筛选和确定超声诊断的早期临床指标。
1실험건립료은정적갑항토불동좌실구형적심장손해모형，병응용분자생물학방법연구갑항토불동좌실구형적B형뇌납태변화급심공능적변화，조출불동좌실구형적갑항토혈장B형뇌납태여기심공능상관성이급여초성각지표변화적상관성。<br>　　2실험적특점재우응용초성신기술대갑항토불동좌실구형적심장손해，병대조병리결과결합혈액생화인자검측진행진단적상규삼수적사선。응용초성신기술급상규초성대갑항환자적심장결구급공능진행평개，사선화학정초성진단적조기림상지표。
BACKGROUND:Toxic effects of excessive thyroid hormone on myocardium can not be ignored with the increased incidence of hyperthyroidism. As a quantitative marker of heart failure, brain natriuretic peptide has a good application prospect to estimate the changes of cardiac function and myocardial damage in hyperthyroid cardiomyopathy. OBJECTIVE:To explore the correlation of brain natriuretic peptide and cardiac function of rabbits with hyperthyroid cardiomyopathy exhibiting different left ventricular geometries. METHODS:Twenty New Zealand purebred rabbits were used in this study. Hyperthyroidism model was established by intraperitoneal injection of levothyroxine (45 μg/kg) for 4 weeks. The success of establishing model is defined upon the appearance of irritation, decreased body weight and increased appetite. Totaly 18 rats were successfuly established. The left ventricular data of hyperthyroidism rabbits were measured by conventional echocardiography. According to the classification of Ganauet al, the 18 hyperthyroidism rabbits were divided into two groups: concentric hypertrophy (n=7) and eccentric hypertrophy (n=11). In addition, ten rats, receiving intraperitoneal injection of 5 mL saline per day, were taken as the control group. RESULTS AND CONCLUSION: Plasma brain natriuretic peptide level of rabbits in the concentric hypertrophy and eccentric hypertrophy groups was obviously higher than that of the control group (alP < 0.01), and the level in the eccentric hypertrophy group was obviously higher than in the concentric hypertrophy group (P< 0.01). Compared with the control group, the average peak diastolic velocity of mitral ring was significantly lower in the concentric hypertrophy and eccentric hypertrophy groups (alP< 0.01), the average peak systolic velocity of mitral ring was also lower in the eccentric hypertrophy group (P < 0.01). The peak systolic and diastolic velocity had a negative correlation with brain natriuretic peptide (alP < 0.01). Experimental findings indicate that brain natriuretic peptide is a sensitive indicator to reflect the cardiac function and myocardial damage in rabbits with hyperthyroid cardiomyopathy, exhibiting different left ventricular geomeies.