中国临床新医学
中國臨床新醫學
중국림상신의학
Chinese Journal of New Clinical Medicine
2015年
10期
949-952
,共4页
多囊卵巢综合征%达英-35%二甲双胍%妊娠%排卵
多囊卵巢綜閤徵%達英-35%二甲雙胍%妊娠%排卵
다낭란소종합정%체영-35%이갑쌍고%임신%배란
Polycystic ovary syndrome( PCOS)%Dyne-35%Metformin%Pregnancy%Ovulation
目的：观察二甲双胍联合达英-35治疗多囊卵巢综合征的疗效及对排卵率和妊娠率的影响。方法对该院接收的68例多囊卵巢综合征患者随机分为A组和B组，每组34例。 A组给予二甲双胍联合达英-35治疗，停药后服用克罗米芬，B组仅服用克罗米芬治疗，两组均治疗80个周期。对比分析两组的临床疗效及排卵率与妊娠率。结果 A组患者经过治疗后，痤疮、闭经、月经稀发明显改善（P＜0.05），而治疗前后多毛改善均不明显（P＞0.05），生殖内分泌激素[促卵泡激素（FSH）、促黄体激素（LH）、雌二醇（E2）、睾酮（T）]与治疗前相比均下降（P＜0.05）。 B组治疗结果类似。两组相比差异无统计学意义（P＞0.05）。 A组的排卵率为72.50％，妊娠率为32.35％，均显著高于B组（分别为53.75％、8.82％），P＜0.05。结论多囊卵巢综合征患者采用二甲双胍联合达英-35治疗，能有效改善月经不规律、痤疮以及高雄激素体征等症状，调整体内生殖内分泌激素水平，显著提高患者的排卵率与妊娠率。
目的：觀察二甲雙胍聯閤達英-35治療多囊卵巢綜閤徵的療效及對排卵率和妊娠率的影響。方法對該院接收的68例多囊卵巢綜閤徵患者隨機分為A組和B組，每組34例。 A組給予二甲雙胍聯閤達英-35治療，停藥後服用剋囉米芬，B組僅服用剋囉米芬治療，兩組均治療80箇週期。對比分析兩組的臨床療效及排卵率與妊娠率。結果 A組患者經過治療後，痤瘡、閉經、月經稀髮明顯改善（P＜0.05），而治療前後多毛改善均不明顯（P＞0.05），生殖內分泌激素[促卵泡激素（FSH）、促黃體激素（LH）、雌二醇（E2）、睪酮（T）]與治療前相比均下降（P＜0.05）。 B組治療結果類似。兩組相比差異無統計學意義（P＞0.05）。 A組的排卵率為72.50％，妊娠率為32.35％，均顯著高于B組（分彆為53.75％、8.82％），P＜0.05。結論多囊卵巢綜閤徵患者採用二甲雙胍聯閤達英-35治療，能有效改善月經不規律、痤瘡以及高雄激素體徵等癥狀，調整體內生殖內分泌激素水平，顯著提高患者的排卵率與妊娠率。
목적：관찰이갑쌍고연합체영-35치료다낭란소종합정적료효급대배란솔화임신솔적영향。방법대해원접수적68례다낭란소종합정환자수궤분위A조화B조，매조34례。 A조급여이갑쌍고연합체영-35치료，정약후복용극라미분，B조부복용극라미분치료，량조균치료80개주기。대비분석량조적림상료효급배란솔여임신솔。결과 A조환자경과치료후，좌창、폐경、월경희발명현개선（P＜0.05），이치료전후다모개선균불명현（P＞0.05），생식내분비격소[촉란포격소（FSH）、촉황체격소（LH）、자이순（E2）、고동（T）]여치료전상비균하강（P＜0.05）。 B조치료결과유사。량조상비차이무통계학의의（P＞0.05）。 A조적배란솔위72.50％，임신솔위32.35％，균현저고우B조（분별위53.75％、8.82％），P＜0.05。결론다낭란소종합정환자채용이갑쌍고연합체영-35치료，능유효개선월경불규률、좌창이급고웅격소체정등증상，조정체내생식내분비격소수평，현저제고환자적배란솔여임신솔。
Objective To observe the curative effect of metformin in combination with dyne-35 on the treat-ment of polycystic ovary syndrome and on the ovulation rate and pregnancy rate.Methods Sixty-eight patients with polycystic ovary syndrome in our hospital were randomly divided into group A and group B, with 34 cases in each group.Group A was given metformin combined with dyne-35 and then G′Finn after withdrawing the above medica-tion.Group B was given G′Finn treatment alone.Both of the two groups were treated with 80 circles.The ovulation rate and the pregnancy rate were compared between the two groups.Results Acne, amenorrhea and menstrual thin hair improved significantly in group A after the treatment(P<0.05), while hairy improvement was not obvious after the treatment(P>0.05).Reproductive endocrine hormones(FSH, LH, E2, T) of group A decreased obviously compared with those before the treatment(P<0.05).The similar results occurred in group B.There was no signifi-cant difference between group A and group B ( P >0.05 ) .The ovulation rate ( 72.50%) and pregnancy rate (32.35%) of group A were significantly higher than those of group B(53.75%, 8.82%)(P<0.05).Conclusion In patients with polycystic ovary syndrome, using metformin combined with dyne-35 treatment can effectively improve irregular menstruation, acne, and symptoms such as high androgen signs, adjust the reproductive endocrine hormone level inside body, significantly increase the ovulation rate and pregnancy rate.
