CAJ | 학술논문

目的：探讨社区获得性肺炎金黄色葡萄球菌的表型及耐药性。方法选取社区获得性金黄色葡萄球菌肺炎患者100例。对13种抗菌药进行耐药表型检测,同时检测菌株mecA和β-内酰胺酶基因；单因素和Logistic分析,筛选影响耐药性的危险因素。结果100株菌株,37株耐甲氧西林,63株敏感,37株携带mecA基因,mecA与表型检测无明显差异(P >0．05)。37株 MRSA 中,28株β-内酰胺酶基因阳性,63株MSSA中,35株阳性,存在显著性差异(P<0．05)。 Logistic分析筛选出影响细菌耐药性的危险因素。结论社区获得性肺炎金黄色葡萄球菌耐药性严重,耐药性发生与携带mecAβ-内酰胺酶基因相关。年龄、感染前是否使用抗生素、糖尿病和免疫疾病史是影响耐药性的危险因素。
목적：탐토사구획득성폐염금황색포도구균적표형급내약성。방법선취사구획득성금황색포도구균폐염환자100례。대13충항균약진행내약표형검측,동시검측균주mecA화β-내선알매기인；단인소화Logistic분석,사선영향내약성적위험인소。결과100주균주,37주내갑양서림,63주민감,37주휴대mecA기인,mecA여표형검측무명현차이(P >0．05)。37주 MRSA 중,28주β-내선알매기인양성,63주MSSA중,35주양성,존재현저성차이(P<0．05)。 Logistic분석사선출영향세균내약성적위험인소。결론사구획득성폐염금황색포도구균내약성엄중,내약성발생여휴대mecAβ-내선알매기인상관。년령、감염전시부사용항생소、당뇨병화면역질병사시영향내약성적위험인소。
Objective To research the characteristics and drug resistance of staphylococcus aureus in com-munity-acquired pneumonia. Methods 100 patients with community-acquired pneumonia infected with staphylococ-cus were selected. Drug resistance of 13 kinds of antibiotics were detected and the mecA and beta lactamase genes were detected. Single factor and logistic regression analysis were selected to screen the risk factors of bacterial drug resistance. Results Among the 100 strains, 37 strains were resistant to methicillin, and 63 strains were sensitive to methicillin. 37 strains were carrying mecA gene, and there was no significant difference between mecA gene detection results and drug resistance detection results ( P>0. 05 ) . Among 37 strains of MRSA, 28 strains of beta lactamase gene were positive. 35 out of 63 strains of MSSA were positive ( P<0. 05 ) . Conclusion The drug resistance of staphylococcus aureus in community acquired pneumonia is serious. The occurrence of drug resistance is closely relat-ed with mecA gene and beta lactamase genes. Age, whether the use of antibiotics before infection, diabetes and other basic disease and immune disease history are the independent risk factors of community-acquired pneumonia.