CAJ | 학술논문

目的：探讨使用Narcotrend指导重症呼吸科患者使用右美托咪定镇静的个体化相关性研究，以达到降低药物副作用的目的。方法选取54例重症呼吸科患者，随机分为两组，给予右美托咪定镇静治疗，实验组以NTI值( Narcotrend检测仪根据镇静患者脑电信号量化形成的0~100的数值，用以客观反映镇静深度)75~85为目标调节泵速。对照组将Narcotrend监测仪显示屏幕反转，专人记录NTI数值，以镇静/警觉( OAA/S)评分3~4级为目标值调节泵速。分别记录生命体征，镇静深度，动脉血气变化情况，比较两组间上述指标差异。结果两组间比较，同一时间段NTI及OAA/S评分变化一致，差异无统计学意义( P>0．05)。结论 Narcotrend能准确有效显示重症呼吸科患者使用右美托咪定的镇静深度，且数据客观连续，为重症呼吸科患者镇静，提供新的依据。
목적：탐토사용Narcotrend지도중증호흡과환자사용우미탁미정진정적개체화상관성연구，이체도강저약물부작용적목적。방법선취54례중증호흡과환자，수궤분위량조，급여우미탁미정진정치료，실험조이NTI치( Narcotrend검측의근거진정환자뇌전신호양화형성적0~100적수치，용이객관반영진정심도)75~85위목표조절빙속。대조조장Narcotrend감측의현시병막반전，전인기록NTI수치，이진정/경각( OAA/S)평분3~4급위목표치조절빙속。분별기록생명체정，진정심도，동맥혈기변화정황，비교량조간상술지표차이。결과량조간비교，동일시간단NTI급OAA/S평분변화일치，차이무통계학의의( P>0．05)。결론 Narcotrend능준학유효현시중증호흡과환자사용우미탁미정적진정심도，차수거객관련속，위중증호흡과환자진정，제공신적의거。
Objective To explore the application value of Narcotrend in guiding the use of dexmedetomidine sedation in intensive care unit of respiratory. Methods 54 patients in respiratory IC were randomly divided into the experimental group and the control group. All patients were given dexmedetomidine sedation. The experimental group adjusted the dexmedetomidine dose to achieve NTI values 75~85 ( narcotrend detector displaying 0~100 according to EEG of patients to reflect the depth of sedation) , and the control group adjusted the dexmedetomidine dose to a-chieve OAA/S score 3~4 scale. The vital signs, degree of sedation and blood gas changes were recorded and comp-ered between the two groups. Results NTI and OAA/S score had no statistically significant difference between the two groups at the same time. Conclusion Narcotrend can accurately and effectively reflect the degree of sedation of patients in respiratory ICU, and the data are objective and continuous, which can provide a new means to guide seda-tion.