CAJ | 학술논문

目的：观察沙培林雾化吸入联合NP方案治疗晚期非小细胞肺癌的临床疗效及其对T细胞亚群的影响。方法：选取本院收治的晚期非小细胞肺癌患者68例，随机分为沙培林雾化吸入联合NP方案组（O-NP组）及单纯NP方案组（NP组），每组各34例，比较两组治疗后的临床疗效及T细胞亚群水平。结果：O-NP组的临床疗效明显优于NP组，两组比较差异有统计学意义（P<0.05）；O-NP组治疗后T细胞亚群水平明显优于治疗前，也明显优于NP组，差异均有统计学意义（P<0.05）。结论：沙培林雾化吸入联合NP方案治疗晚期非小细胞肺癌的疗效显著，可有效改善患者免疫功能，值得临床推广应用。
목적：관찰사배림무화흡입연합NP방안치료만기비소세포폐암적림상료효급기대T세포아군적영향。방법：선취본원수치적만기비소세포폐암환자68례，수궤분위사배림무화흡입연합NP방안조（O-NP조）급단순NP방안조（NP조），매조각34례，비교량조치료후적림상료효급T세포아군수평。결과：O-NP조적림상료효명현우우NP조，량조비교차이유통계학의의（P<0.05）；O-NP조치료후T세포아군수평명현우우치료전，야명현우우NP조，차이균유통계학의의（P<0.05）。결론：사배림무화흡입연합NP방안치료만기비소세포폐암적료효현저，가유효개선환자면역공능，치득림상추엄응용。
Objective:To observe the clinical effect of Sapylin inhalation combined with NP regimen for the treatment of advanced non-small cell lung cancer and its effects on the T lymphocyte subsets.Method:68 cases of advanced non-small cell lung cancer in our hospital were selected,they were randomly divided into inhalation combined with NP regimen group(O-NP group)and NP regimen alone group(NP group),34 cases in each group. The clinical efficacy of the two groups after treatment and the level of T cells subsets before and after treatment were compared.Result:The clinical effect of O-NP group was significantly better than that of NP group,the difference was statistically significant(P<0.05).In O-NP group,the T cells subgroup level after treatment was significantly better than before,and it was also significantly better than that in NP group,the differences were statistically significant(P<0.05). Conclusion:Sapylin inhalation combined with NP regimen for the treatment of advanced non-small cell lung cancer is effective,can effectively improve the immune function,it is worthy of clinical application.