临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
Clinical Medication Journal
2015年
5期
53-56
,共4页
丙泊酚%依托咪酯%全麻%患儿%术后认知功能障碍
丙泊酚%依託咪酯%全痳%患兒%術後認知功能障礙
병박분%의탁미지%전마%환인%술후인지공능장애
propofol%etomidate%anesthesia%children%POCD
目的：探讨幼儿患者采用丙泊酚或依托咪酯全麻对认知功能的影响。方法：选取我院于2014年2月至2015年2月共收治的79例行腹腔镜下疝气修补术的患儿为研究对像，所有患儿以ASA分为I、II级，采用随机数字分组法分为1组39例，采用丙泊酚麻醉；2组40例，采用依托咪酯麻醉。同时，将同年龄段的40名健康幼儿选为3组，与1、2组患儿行对比研究。对1、2组患儿以贝莉婴幼儿认知量表III（Bayley scales of infant and toddler development, BSIDⅢ）分别于术前1 d与术后3 d及3个月后进行认知评估，对应同时期3组幼儿水平，并对1、2组患儿术后认知功能障碍的发生率进行有效计算。结果：1、2两组患儿术后3 d认识水平与术前相比有所下降，差异有统计学意义（P<0.05），1组术后认知功能障碍（POCD）患儿8例，2组11例；1、2组患儿术后3 d的POCD发生情况与术后1 d对比无明显差别，P>0.05；1、2组患儿术后3个月认知水平与POCD发生率与术前相比无差异（P>0.05）。结论：对患儿行丙泊酚或依托咪酯全麻后，对患儿短期内认知功能有所影响，但能在3个月内自行恢复。
目的：探討幼兒患者採用丙泊酚或依託咪酯全痳對認知功能的影響。方法：選取我院于2014年2月至2015年2月共收治的79例行腹腔鏡下疝氣脩補術的患兒為研究對像，所有患兒以ASA分為I、II級，採用隨機數字分組法分為1組39例，採用丙泊酚痳醉；2組40例，採用依託咪酯痳醉。同時，將同年齡段的40名健康幼兒選為3組，與1、2組患兒行對比研究。對1、2組患兒以貝莉嬰幼兒認知量錶III（Bayley scales of infant and toddler development, BSIDⅢ）分彆于術前1 d與術後3 d及3箇月後進行認知評估，對應同時期3組幼兒水平，併對1、2組患兒術後認知功能障礙的髮生率進行有效計算。結果：1、2兩組患兒術後3 d認識水平與術前相比有所下降，差異有統計學意義（P<0.05），1組術後認知功能障礙（POCD）患兒8例，2組11例；1、2組患兒術後3 d的POCD髮生情況與術後1 d對比無明顯差彆，P>0.05；1、2組患兒術後3箇月認知水平與POCD髮生率與術前相比無差異（P>0.05）。結論：對患兒行丙泊酚或依託咪酯全痳後，對患兒短期內認知功能有所影響，但能在3箇月內自行恢複。
목적：탐토유인환자채용병박분혹의탁미지전마대인지공능적영향。방법：선취아원우2014년2월지2015년2월공수치적79례행복강경하산기수보술적환인위연구대상，소유환인이ASA분위I、II급，채용수궤수자분조법분위1조39례，채용병박분마취；2조40례，채용의탁미지마취。동시，장동년령단적40명건강유인선위3조，여1、2조환인행대비연구。대1、2조환인이패리영유인인지량표III（Bayley scales of infant and toddler development, BSIDⅢ）분별우술전1 d여술후3 d급3개월후진행인지평고，대응동시기3조유인수평，병대1、2조환인술후인지공능장애적발생솔진행유효계산。결과：1、2량조환인술후3 d인식수평여술전상비유소하강，차이유통계학의의（P<0.05），1조술후인지공능장애（POCD）환인8례，2조11례；1、2조환인술후3 d적POCD발생정황여술후1 d대비무명현차별，P>0.05；1、2조환인술후3개월인지수평여POCD발생솔여술전상비무차이（P>0.05）。결론：대환인행병박분혹의탁미지전마후，대환인단기내인지공능유소영향，단능재3개월내자행회복。
Objective: To investigate the effects of anesthesia using propofol or etomidate on cognitive function in infants.Methods: From February 2014 to February 2015, 79 cases of children undergoing laparoscopic surgery on hernia repair in our hospital were studied. All the children were divided into Grade I and II by ASA. They were divided into group 1 (n=39) using propofol anesthesia and group 2 (n=40) using etomidate anesthesia randomly according to random numbers. Another 40 healthy children with the same age were in group 3. A comparative study on the adverse effects was performed between Group1or 2 and Group 3. In group 1 and 2, cognitive function of children were assessed using BSID III 1 day before operation, 3 days and 3 months after operation, respectively. Compared with cognitive function in group 3, the incidence of postoperative cognitive dysfunction of children in group 1, 2 were estimated.Results: The cognitive levels of group 1 and 2 all signiifcantly decreased at the third day postoperation compared with those before operation (P<0.05). There were 8 cases of POCD children in group1 and 11 cases in group 2. However, there was no signiifcant difference in the occurring condition of POCD between the 3 days and 1 day after operation a in group 1and 2. (P>0.05). The cognitive level and occurring condition of POCD in group 1 and 2 showed no signiifcant difference 3 months after operation and before operation (P<0.05).Conclusion: Propofol or etomidate anesthesia might have some inlfuence on the cognitive function of children in a short time, which can revert spontaneously in three months.
