CAJ | 학술논문

目的：分析贝那普利联合氨氯地平治疗难治性高血压的疗效。方法回顾性分析我院2014年2月~2015年2月收治的128例难治性高血压患者的临床资料，按不同的治疗方案分为两组，各64例，对照组予以贝那普利治疗，研究组予以贝那普利联合氨氯地平治疗，比较两组治疗前后血压变化情况、临床疗效及不良反应情况。结果研究组治疗后血压水平下降幅度较对照组高，总有效率为92.19%，高于对照组的57.81%，差异有统计学意义（P<0.05）；研究组不良反应总发生率为9.38%，较对照组的4.69%略高，差异无统计学意义（P>0.05）。结论贝那普利联合氨氯地平治疗难治性高血压疗效确切，可有效降低血压，且安全性高，值得临床推广应用。
목적：분석패나보리연합안록지평치료난치성고혈압적료효。방법회고성분석아원2014년2월~2015년2월수치적128례난치성고혈압환자적림상자료，안불동적치료방안분위량조，각64례，대조조여이패나보리치료，연구조여이패나보리연합안록지평치료，비교량조치료전후혈압변화정황、림상료효급불량반응정황。결과연구조치료후혈압수평하강폭도교대조조고，총유효솔위92.19%，고우대조조적57.81%，차이유통계학의의（P<0.05）；연구조불량반응총발생솔위9.38%，교대조조적4.69%략고，차이무통계학의의（P>0.05）。결론패나보리연합안록지평치료난치성고혈압료효학절，가유효강저혈압，차안전성고，치득림상추엄응용。
Objective To analyze the effect of benazepril combined with amlodipine in the treatment of refractory hy-pertension. Methods The clinical data of 128 patients with refractory hypertension treated in our hospital from Febru-ary 2014 to February 2015 were reviewed and divided into two groups,with 64 cases in each group,according to the dif-ferent treatments given.Patients in control group were treated with benazepril,whereas those in study group were given benazepril combined with amlodipine for treatment.The changes in blood pressure,clinical efficacy and adverse reac-tions before and after treatment were compared between two groups. Results The blood pressure levels after the treat-ment decreased more significantly in study group than control group,and the total efficiency in study group was 92.19%, higher than that in control group,which was 57.81%,with statistical difference (P<0.05).The total incidence of adverse drug reactions in study group was 9.38%,slightly higher than that of control group,which was 4.69%,yet without signifi-cant difference(P>0.05). Conclusion Benazepril combined with amlodipine is very effective in the treatment of refracto-ry hypertension,which can effectively reduce blood pressure,yet with security,thus it is worth clinical application.