CAJ | 학술논문

目的：探讨碘酊烧灼联合氟康唑和二性霉素B治疗真菌性角膜炎的临床效果。方法选取2014年3~10月我院收治的真菌性角膜炎患者84例，随机分为三联组和二联组，二联组采用氟康唑联合二性霉素B治疗，三联组采用碘酊烧灼联合氟康唑和二性霉素B治疗，比较两组患者的症状消失时间和治疗效果。结果三联组患者角膜溃疡、前房脓肿、异物感、畏光流泪的临床症状消失时间均短于二联组[（20.5±2.6）d vs（24.8±2.9）d，（18.8±2.4）d vs（23.4±2.7）d，（15.4±2.0）d vs（17.8±2.2）d，（21.2±2.8）d vs（26.6±2.9）d]（P<0.05）。三联组的治疗效果显著优于二联组（总有效率：97.62%v s 83.33%）（P<0.05）。结论碘酊烧灼联合氟康唑和二性霉素B治疗真菌性角膜炎可缩短患者的症状消失时间，提高治疗效果。
목적：탐토전정소작연합불강서화이성매소B치료진균성각막염적림상효과。방법선취2014년3~10월아원수치적진균성각막염환자84례，수궤분위삼련조화이련조，이련조채용불강서연합이성매소B치료，삼련조채용전정소작연합불강서화이성매소B치료，비교량조환자적증상소실시간화치료효과。결과삼련조환자각막궤양、전방농종、이물감、외광류루적림상증상소실시간균단우이련조[（20.5±2.6）d vs（24.8±2.9）d，（18.8±2.4）d vs（23.4±2.7）d，（15.4±2.0）d vs（17.8±2.2）d，（21.2±2.8）d vs（26.6±2.9）d]（P<0.05）。삼련조적치료효과현저우우이련조（총유효솔：97.62%v s 83.33%）（P<0.05）。결론전정소작연합불강서화이성매소B치료진균성각막염가축단환자적증상소실시간，제고치료효과。
Objective To evaluate the clinical effect of iodine burning combined with fluconazole and amphotericin B treating fungal keratitis. Methods 84 cases with fungal keratitis treated in our hospital from March to October 2014 were selected and they were randomly divided into triple group and bivalent group,bivalent group was given fluconazole combined with amphotericin B,and triple group was given iodine burning combined with fluconazole and amphotericin B.The disappearing time of symptom and treatment effect in patients between two groups was compared respectively. Results The disappearing time of clinical symptom of corneal ulcer,anterior abscess,foreign body sensation,photophobia, tearing in bivalent group was shorter than that of bivalent group respectively [(20.5±2.6)d vs (24.8±2.9)d,(18.8±2.4)d vs (23.4±2.7)d,(15.4±2.0)d vs (17.8±2.2)d,(21.2±2.8)d vs (26.6±2.9)d) (P<0.05].Treatment effect of triple group was obvi-ously better than that of bivalent group (the total effective rate:97.62% vs 83.33%) (P<0.05). Conclusion Iodine burn-ing combined with fluconazole and amphotericin B treating fungal keratitis may shorten the disappearing time of symp-tom in patients and improve the treatment effect.