中国保健营养
中國保健營養
중국보건영양
China Health Care & Nutrition
2015年
7期
2-3,5
,共3页
miR-720%乳腺癌%淋巴结转移%预后
miR-720%乳腺癌%淋巴結轉移%預後
miR-720%유선암%림파결전이%예후
MicroRNA-720%Breast cancer%Lymph node metastasis%Prognosis
目的：：探讨 miR－720在乳腺癌中的表达水平与临床病理特征的关系.方法：应用 QuanG titative stem－loop RT – PCR 检测110例乳腺癌组织中 miR－720的表达水平,分析其与乳腺癌患者临床病理特征的关系.结果：miR－720表达水平与乳腺癌患者首诊时淋巴结是否转移有关(P ＝0．001).在首诊有淋巴结转移的病例中,miR－720高表达组5年生存率高于 miR－720低表达组(P ＝0．038).结论：miR－720在乳腺癌组织的表达水平与患者的淋巴结转移及预后密切相关,可能成为乳腺癌诊断及预后判断的新的分子标志.
目的：：探討 miR－720在乳腺癌中的錶達水平與臨床病理特徵的關繫.方法：應用 QuanG titative stem－loop RT – PCR 檢測110例乳腺癌組織中 miR－720的錶達水平,分析其與乳腺癌患者臨床病理特徵的關繫.結果：miR－720錶達水平與乳腺癌患者首診時淋巴結是否轉移有關(P ＝0．001).在首診有淋巴結轉移的病例中,miR－720高錶達組5年生存率高于 miR－720低錶達組(P ＝0．038).結論：miR－720在乳腺癌組織的錶達水平與患者的淋巴結轉移及預後密切相關,可能成為乳腺癌診斷及預後判斷的新的分子標誌.
목적：：탐토 miR－720재유선암중적표체수평여림상병리특정적관계.방법：응용 QuanG titative stem－loop RT – PCR 검측110례유선암조직중 miR－720적표체수평,분석기여유선암환자림상병리특정적관계.결과：miR－720표체수평여유선암환자수진시림파결시부전이유관(P ＝0．001).재수진유림파결전이적병례중,miR－720고표체조5년생존솔고우 miR－720저표체조(P ＝0．038).결론：miR－720재유선암조직적표체수평여환자적림파결전이급예후밀절상관,가능성위유선암진단급예후판단적신적분자표지.
Objective:To investigate the expression level of miR-720 in breast cancer and its relationship with clinicopathological features of breast cancer(BC).Methods:The method of quantitaG tive stem- loop RT – PCR was used to detect the expression levels of miR - 720 in 1 10 cases of breast cancer tissue and analyze its relationship with clinical pathological characteristics of BC patients. Results:The expression of miR-720 is associated with lymph node metastasis states when initially diG agnosed(P =0.001).When initially diagnosed with lymph node metastasis,five-year survival rate of miR-720 high expression group was higher than that of miR-720 low expression one (P =0.038). Conclusion:miR-720 expression level is closely correlated with the lymph node metastasis and progG nosis of patients with BC and may serve as a potent molecular marker for BC diagnosis and prognostic assessment.
