CAJ | 학술논문

目的：探讨厄贝沙坦联合氨氯地平治疗高血压合并糖尿病肾病的治疗效果。方法选择我院2011年3月~2014年3月收治的糖尿病肾病合并高血压的患者150例作为本次的研究对象，随机分为3组，每组50例，根据给药情况分别为厄贝沙坦组（A组）、氨氯地平组（B组）、厄贝沙坦联合氨氯地平组（C组）。治疗10周后对3组患者的血压、尿β2-微球蛋白、24 h尿白蛋白及24 h尿蛋白定量进行比较。结果治疗后，3组患者的血压均下降至正常水平，C组血压显著低于A组和B组，差异有统计学意义（P<0.05）；治疗后3组患者的尿液检查相关指标亦显著降低，与A组和B组比较，C组的24 h尿白蛋白、24 h尿蛋白定量和尿β2-微球蛋白等均显著降低，差异有统计学意义（P<0.05）。结论与单独用药比较，厄贝沙坦联合氨氯地平治疗高血压合并糖尿病肾病疗效更加显著，值得临床推广。
목적：탐토액패사탄연합안록지평치료고혈압합병당뇨병신병적치료효과。방법선택아원2011년3월~2014년3월수치적당뇨병신병합병고혈압적환자150례작위본차적연구대상，수궤분위3조，매조50례，근거급약정황분별위액패사탄조（A조）、안록지평조（B조）、액패사탄연합안록지평조（C조）。치료10주후대3조환자적혈압、뇨β2-미구단백、24 h뇨백단백급24 h뇨단백정량진행비교。결과치료후，3조환자적혈압균하강지정상수평，C조혈압현저저우A조화B조，차이유통계학의의（P<0.05）；치료후3조환자적뇨액검사상관지표역현저강저，여A조화B조비교，C조적24 h뇨백단백、24 h뇨단백정량화뇨β2-미구단백등균현저강저，차이유통계학의의（P<0.05）。결론여단독용약비교，액패사탄연합안록지평치료고혈압합병당뇨병신병료효경가현저，치득림상추엄。
Objective To explore the therapeutic efficacy of irbesartan combined amlodipine for the treatment of hyper-tension and diabetic nephropathy. Methods 150 patients with diabetic nephropathy and hypertension received in our hospital from March 2011 to March 2014 were randomly divided into irbesartan group(group A),amlodipine group(group B),irbesartan and amlodipine group (group C) according to its administration circumstances,with 50 patients in each group.Blood pressure,urine β2-microglobulin,24 h urine albumin and 24 h urinary protein excretion were observed and compared after 10 weeks of treatment. Results The blood pressure in patients among three groups was dropped to nor-mal after treatment respectively,but the one in group C was significantly lower than group A and group B (P<0.05);The urine tests related indicators of patients among three groups was also significantly reduced respectively after treatment, but 24 h urine albumin,24 h urinary protein excretion and urine β2-microglobulin etc in group A was significantly low-er than group A and group B respectively (P<0.05). Conclusion Irbesartan combined amlodipine in the treatment of hypertension and diabetic nephropathy has significant efficacy compared to single drug,which is worthy of promotion.