中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
28期
35-37
,共3页
胃癌%VEGF%SSTR%相关性
胃癌%VEGF%SSTR%相關性
위암%VEGF%SSTR%상관성
Gastric cancer%VEGF%SSTR%Correlation
目的：探讨胃癌患者VEGF与SSTR表达以及两者之间的相关性。方法：选取2010年1月-2014年12月就诊于本院的胃癌患者90例作为胃癌组，另取同期于本院体检的60例健康者作为对照组，采用免疫组织化学染色检测VEGF及SSTR在不同胃黏膜组织中的表达情况。结果：胃癌组VEGF表达阳性56例，阳性率为62.2%；对照组正常胃黏膜组中VEGF表达阳性5例，阳性率为8.3%，胃癌组VEGF表达阳性率高于对照组，比较差异具有统计学意义（P<0.05）。胃癌组SSTR1表达阳性73例，阳性率为81.1%，SSTR2表达阳性67例，阳性率为74.4%，SSTR3表达阳性47例，阳性率为52.2%。对照组SSTR1表达阳性47例，阳性率为78.3%，SSTR2表达阳性56例，阳性率为93.3%，SSTR3表达阳性51例，阳性率为85.5%。两组SSTR1阳性表达率比较差异无统计学意义（P>0.05），胃癌组SSTR2、SSTR3表达阳性率低于对照组，比较差异具有统计学意义（P<0.05）。VEGF与SSTR2~3在胃癌组织中的表达存在显著相关性（P<0.05），而与SSTR1的表达并未见显著相关性（P>0.05）。结论：VEGF在胃癌组织中高表达，而SSTR在胃癌组织中低表达，两者间呈显著负相关，表明在胃癌的发生发展调控中信号传导在上调VEGF的同时造成SSTR的丢失。
目的：探討胃癌患者VEGF與SSTR錶達以及兩者之間的相關性。方法：選取2010年1月-2014年12月就診于本院的胃癌患者90例作為胃癌組，另取同期于本院體檢的60例健康者作為對照組，採用免疫組織化學染色檢測VEGF及SSTR在不同胃黏膜組織中的錶達情況。結果：胃癌組VEGF錶達暘性56例，暘性率為62.2%；對照組正常胃黏膜組中VEGF錶達暘性5例，暘性率為8.3%，胃癌組VEGF錶達暘性率高于對照組，比較差異具有統計學意義（P<0.05）。胃癌組SSTR1錶達暘性73例，暘性率為81.1%，SSTR2錶達暘性67例，暘性率為74.4%，SSTR3錶達暘性47例，暘性率為52.2%。對照組SSTR1錶達暘性47例，暘性率為78.3%，SSTR2錶達暘性56例，暘性率為93.3%，SSTR3錶達暘性51例，暘性率為85.5%。兩組SSTR1暘性錶達率比較差異無統計學意義（P>0.05），胃癌組SSTR2、SSTR3錶達暘性率低于對照組，比較差異具有統計學意義（P<0.05）。VEGF與SSTR2~3在胃癌組織中的錶達存在顯著相關性（P<0.05），而與SSTR1的錶達併未見顯著相關性（P>0.05）。結論：VEGF在胃癌組織中高錶達，而SSTR在胃癌組織中低錶達，兩者間呈顯著負相關，錶明在胃癌的髮生髮展調控中信號傳導在上調VEGF的同時造成SSTR的丟失。
목적：탐토위암환자VEGF여SSTR표체이급량자지간적상관성。방법：선취2010년1월-2014년12월취진우본원적위암환자90례작위위암조，령취동기우본원체검적60례건강자작위대조조，채용면역조직화학염색검측VEGF급SSTR재불동위점막조직중적표체정황。결과：위암조VEGF표체양성56례，양성솔위62.2%；대조조정상위점막조중VEGF표체양성5례，양성솔위8.3%，위암조VEGF표체양성솔고우대조조，비교차이구유통계학의의（P<0.05）。위암조SSTR1표체양성73례，양성솔위81.1%，SSTR2표체양성67례，양성솔위74.4%，SSTR3표체양성47례，양성솔위52.2%。대조조SSTR1표체양성47례，양성솔위78.3%，SSTR2표체양성56례，양성솔위93.3%，SSTR3표체양성51례，양성솔위85.5%。량조SSTR1양성표체솔비교차이무통계학의의（P>0.05），위암조SSTR2、SSTR3표체양성솔저우대조조，비교차이구유통계학의의（P<0.05）。VEGF여SSTR2~3재위암조직중적표체존재현저상관성（P<0.05），이여SSTR1적표체병미견현저상관성（P>0.05）。결론：VEGF재위암조직중고표체，이SSTR재위암조직중저표체，량자간정현저부상관，표명재위암적발생발전조공중신호전도재상조VEGF적동시조성SSTR적주실。
Objective:To study the expression of VEGF and SSTR and their correlations in patients with gastric cancer. Method:90 patients with gastric cancer treated from January 2010 to December 2014 in our hospital were selected as gastric cancer group and 60 healthy check-ups were selected as control group. Through immunohistochemistry staining methods,the expression of VEGF and SSTR in different gastric mucosa tissues were detected. Result:The positive rate of VEFG in gastric cancer group was 62.2%(56 cases);the positive rate of VEGF in the control group was 8.3%(5 cases)(P<0.05);the gastric cancer group contained 73 positive cases in SSTR1(81.1%),67 positive cases in SSTR2(74.4%)and 47 positive cases in SSTR3(52.2%);the control group contained 47 positive cases in SSTR1(78.3%),56 positive cases in SSTR2(93.3%)and 51 positive cases in SSTR3 (85.5%);the positive expression of SSTR1 of the two groups was not significantly different(P>0.05);the positive rate of SSTR2 and SSTR3 of the gastric cancer group was lower than that of the control group(P<0.05). VEGF expression was significantly correlated with SSTR2 and SSTR3 expression in gastric cancer tissues(P<0.05);VEGF expression was not closely correlated with SSTR1 expression(P>0.05). Conclusion:VEGF is highly expressed while SSTR is lowly expressed in gastric cancer tissues. VEGF is negatively correlated with SSTR,which indicates that the up-regulation of VEGF during signal transduction of occurrence and development of gastric cancer will cause the loss of SSTR.
