中国感染与化疗杂志
中國感染與化療雜誌
중국감염여화료잡지
Chinese Journal of Infection and Chemotherapy
2015年
5期
439-442
,共4页
唐晓华%唐希才%杨卫琴%黄结贞%欧子豪
唐曉華%唐希纔%楊衛琴%黃結貞%歐子豪
당효화%당희재%양위금%황결정%구자호
早产低体重儿%血流感染%耐药性
早產低體重兒%血流感染%耐藥性
조산저체중인%혈류감염%내약성
low birth weight preterm infant%bloodstream infection%antibiotic resistance
目的：了解医院早产低体重儿（preterm low birth weigh ，PLBW）血流感染病原菌分布及药敏情况，为临床诊治提供依据。方法对2011年1月—2014年4月住院治疗的95例PLBW血流感染患儿临床特点及病原学情况进行回顾性分析。结果共检出病原菌96株，其中革兰阴性杆菌57株，革兰阳性球菌38株，阿萨希丝孢酵母1株。最常见细菌为肺炎克雷伯菌（40株）和凝固酶阴性葡萄球菌（31株）。药敏结果显示：革兰阴性杆菌对亚胺培南等碳青霉烯类抗生素均敏感；链球菌对常用抗菌药物敏感率较高；葡萄球菌中，耐甲氧西林葡萄球菌（methicillin‐resistant Staphycoccus ，MRS）检出率高，MRS菌株对多数抗菌药物耐药，对口恶唑烷酮类（利奈唑胺）和糖肽类抗生素（万古霉素和替考拉宁）药物敏感率100％。结论 PLBW血流感染的主要病原菌为肺炎克雷伯菌和凝固酶阴性葡萄球菌，对于PLBW血流感染患儿，应及时完善相关检查并选用合理的抗菌药物进行治疗，改善其预后。
目的：瞭解醫院早產低體重兒（preterm low birth weigh ，PLBW）血流感染病原菌分佈及藥敏情況，為臨床診治提供依據。方法對2011年1月—2014年4月住院治療的95例PLBW血流感染患兒臨床特點及病原學情況進行迴顧性分析。結果共檢齣病原菌96株，其中革蘭陰性桿菌57株，革蘭暘性毬菌38株，阿薩希絲孢酵母1株。最常見細菌為肺炎剋雷伯菌（40株）和凝固酶陰性葡萄毬菌（31株）。藥敏結果顯示：革蘭陰性桿菌對亞胺培南等碳青黴烯類抗生素均敏感；鏈毬菌對常用抗菌藥物敏感率較高；葡萄毬菌中，耐甲氧西林葡萄毬菌（methicillin‐resistant Staphycoccus ，MRS）檢齣率高，MRS菌株對多數抗菌藥物耐藥，對口噁唑烷酮類（利奈唑胺）和糖肽類抗生素（萬古黴素和替攷拉寧）藥物敏感率100％。結論 PLBW血流感染的主要病原菌為肺炎剋雷伯菌和凝固酶陰性葡萄毬菌，對于PLBW血流感染患兒，應及時完善相關檢查併選用閤理的抗菌藥物進行治療，改善其預後。
목적：료해의원조산저체중인（preterm low birth weigh ，PLBW）혈류감염병원균분포급약민정황，위림상진치제공의거。방법대2011년1월—2014년4월주원치료적95례PLBW혈류감염환인림상특점급병원학정황진행회고성분석。결과공검출병원균96주，기중혁란음성간균57주，혁란양성구균38주，아살희사포효모1주。최상견세균위폐염극뢰백균（40주）화응고매음성포도구균（31주）。약민결과현시：혁란음성간균대아알배남등탄청매희류항생소균민감；련구균대상용항균약물민감솔교고；포도구균중，내갑양서림포도구균（methicillin‐resistant Staphycoccus ，MRS）검출솔고，MRS균주대다수항균약물내약，대구악서완동류（리내서알）화당태류항생소（만고매소화체고랍저）약물민감솔100％。결론 PLBW혈류감염적주요병원균위폐염극뢰백균화응고매음성포도구균，대우PLBW혈류감염환인，응급시완선상관검사병선용합리적항균약물진행치료，개선기예후。
Objective To study the etiology and antibiotic resistance of bloodstream infections in low birth weight preterm infants .Methods A total of 95 cases of bloodstream infections in low birth weight preterm infants were treated in our hospital from January 2011 to April 2014 .The clinical data of these patients were analyzed retrospectively .Results A total of 96 pathogens were isolated ,including 57 strains of gram‐negative bacilli ,38 strains of gram‐positive cocci ,and 1 strains of Trichosporon asahii .The most frequently isolated pathogens were Klebsiella pneumoniae (40 strains)and coagulase‐negative Staphylococcus(31 strains).All gram‐negative bacilli were sensitive to carbapenems such as imipenem and panipenem . Streptococcus isolates were sensitive to most antibiotics .Most Staphylococcus isolates were methicillin‐resistant ,which were highly resistant to common antibiotics but all sensitive to linezolid , vancomycin and teicoplanin . Conclusions The most important pathogens responsible for bloodstream infections in low birth weight preterm infants in our hospital are K lebsiella pneumoniae and coagulase‐negative Staphylococcus . Early identification of responsible pathogen and rational antimicrobial therapy are critical for good prognosis of bloodstream infections in low birth weight preterm infants .
