CAJ | 학술논문

目的：观察联合应用大承气汤和血液净化法（CBP)治疗重症急性胰腺炎的临床效果。方法将2013年12月—2014年12月我院重症医学科(ICU)收治的80例重症急性胰腺炎患者作为研究对象，随机将其分为治疗组与对照组，每组各40例患者。对对照组患者进行西医常规治疗，在此基础上为治疗组患者联合应用大承气汤和血液净化法进行治疗，然后对比观察在进行治疗后第4d、第7d两组患APACHEⅡ、CRP、PCT、IL-6、IAP的指标，统计其进行血液净化、机械通气的时间、住ICU的时间及病死率。结果：与对照组患者相比，治疗组患者在进行治疗第4d、第7 d其APACHEⅡ、CRP、PCT、IL-6、IAP的指标较优，差异显著(P<0.05)，有统计学意义。与对照组患者相比，治疗组患者进行机械通气的时间、住ICU的时间较短，病死率较低，差异显著(P<0.05)，有统计学意义。结论：联合应用大承气汤和CBP治疗SAP的效果确切，可显著缩短患者的病程，此法值得在临床上推广应用。
목적：관찰연합응용대승기탕화혈액정화법（CBP)치료중증급성이선염적림상효과。방법장2013년12월—2014년12월아원중증의학과(ICU)수치적80례중증급성이선염환자작위연구대상，수궤장기분위치료조여대조조，매조각40례환자。대대조조환자진행서의상규치료，재차기출상위치료조환자연합응용대승기탕화혈액정화법진행치료，연후대비관찰재진행치료후제4d、제7d량조환APACHEⅡ、CRP、PCT、IL-6、IAP적지표，통계기진행혈액정화、궤계통기적시간、주ICU적시간급병사솔。결과：여대조조환자상비，치료조환자재진행치료제4d、제7 d기APACHEⅡ、CRP、PCT、IL-6、IAP적지표교우，차이현저(P<0.05)，유통계학의의。여대조조환자상비，치료조환자진행궤계통기적시간、주ICU적시간교단，병사솔교저，차이현저(P<0.05)，유통계학의의。결론：연합응용대승기탕화CBP치료SAP적효과학절，가현저축단환자적병정，차법치득재림상상추엄응용。
Objective: To observe the therapeutic effects of Dachengqi decoction (大承气汤) combined with continuous blood purification on severe acute pancreatitis. Methods: 80 patients with Severe acute pancreatitis were selected in the study .The patients were randomly divided into treatment group and control group each 40 cases. treated with routine western medicine, treatment group combined with Dachengqi decoction enema and Continuous blood purification for 7 days, APACHEⅡ, CRP、PCT、IL-6、IAP were observed and compared between the two groups 4 days and 7 days after . CBP time , MV time ,days in icu and mortality rate were observed After treatment . Results: In the treatment Group , APACHEⅡ, CRP, PCT, IL-6, IAP, days in icu and mortality rate were better than those of control group, the differences being significant (P< 0.05). Conclusion: Dachengqi decoction enema combined with continuous blood purification can markedly improve intra-abdominal pressure and Inflammatory markers in patients with Severe acute pancreatitis . shorten days in icu , eventually increase Treatment effect.