中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
27期
91-93
,共3页
柯瑞琼%秦永章%肖丽霞%方向南%洪世华%吕维名
柯瑞瓊%秦永章%肖麗霞%方嚮南%洪世華%呂維名
가서경%진영장%초려하%방향남%홍세화%려유명
格列美脲%预混胰岛素%肥胖%2型糖尿病
格列美脲%預混胰島素%肥胖%2型糖尿病
격렬미뇨%예혼이도소%비반%2형당뇨병
Glimepiride%Premixed insulin%Obese%Type 2 diabetes mellitus
目的:观察继往单用预混胰岛素治疗血糖控制不佳的肥胖2型糖尿病患者加用格列美脲的临床疗效。方法将本院2013年9月~2014年9月60例单用预混胰岛素治疗跃3个月、血糖控制不佳的肥胖2型糖尿病患者随机分为治疗组(A组)和对照组(B组),每组30例,A组患者在调整预混胰岛素剂量的同时,予午餐前口服格列美脲,B组患者维持原治疗方案,继续调整胰岛素剂量,治疗观察3个月,比较治疗前后血糖水平、体质指数(BMI)、胰岛素剂量的变化及低血糖发生情况。结果治疗后两组患者FPG、2 hPG、糖化血红蛋白(HbA1c)较治疗前均显著下降(P<0.05),但A组下降更明显(P<0.05),A组BMI及胰岛素剂量较治疗前显著下降(P<0.05),低血糖发生率为6.7%。B组患者的BMI、胰岛素剂量较治疗前显著增加(P<0.05),低血糖发生率为16.7%。结论对单用预混胰岛素控制不佳的肥胖2型糖尿病患者,加用格列美脲治疗能有效降低整体血糖水平,可显著减少胰岛素用量,且对患者的体重质量有更大的获益。
目的:觀察繼往單用預混胰島素治療血糖控製不佳的肥胖2型糖尿病患者加用格列美脲的臨床療效。方法將本院2013年9月~2014年9月60例單用預混胰島素治療躍3箇月、血糖控製不佳的肥胖2型糖尿病患者隨機分為治療組(A組)和對照組(B組),每組30例,A組患者在調整預混胰島素劑量的同時,予午餐前口服格列美脲,B組患者維持原治療方案,繼續調整胰島素劑量,治療觀察3箇月,比較治療前後血糖水平、體質指數(BMI)、胰島素劑量的變化及低血糖髮生情況。結果治療後兩組患者FPG、2 hPG、糖化血紅蛋白(HbA1c)較治療前均顯著下降(P<0.05),但A組下降更明顯(P<0.05),A組BMI及胰島素劑量較治療前顯著下降(P<0.05),低血糖髮生率為6.7%。B組患者的BMI、胰島素劑量較治療前顯著增加(P<0.05),低血糖髮生率為16.7%。結論對單用預混胰島素控製不佳的肥胖2型糖尿病患者,加用格列美脲治療能有效降低整體血糖水平,可顯著減少胰島素用量,且對患者的體重質量有更大的穫益。
목적:관찰계왕단용예혼이도소치료혈당공제불가적비반2형당뇨병환자가용격렬미뇨적림상료효。방법장본원2013년9월~2014년9월60례단용예혼이도소치료약3개월、혈당공제불가적비반2형당뇨병환자수궤분위치료조(A조)화대조조(B조),매조30례,A조환자재조정예혼이도소제량적동시,여오찬전구복격렬미뇨,B조환자유지원치료방안,계속조정이도소제량,치료관찰3개월,비교치료전후혈당수평、체질지수(BMI)、이도소제량적변화급저혈당발생정황。결과치료후량조환자FPG、2 hPG、당화혈홍단백(HbA1c)교치료전균현저하강(P<0.05),단A조하강경명현(P<0.05),A조BMI급이도소제량교치료전현저하강(P<0.05),저혈당발생솔위6.7%。B조환자적BMI、이도소제량교치료전현저증가(P<0.05),저혈당발생솔위16.7%。결론대단용예혼이도소공제불가적비반2형당뇨병환자,가용격렬미뇨치료능유효강저정체혈당수평,가현저감소이도소용량,차대환자적체중질량유경대적획익。
Objective To observe the clinical effect of glimepiride added to single treated type 2 diabetes patients with poor glycemic control by pre mixed insulin therapy. Methods Sixty ineffective controlled obese type 2 diabetes patients in our hospital from September 2013 to September 2014 were single treated by pre mixed insulin more than 3 months were randomly divided into two groups,treatment group(group A)received aspart 30 combined with glimepiride and con-trol group(group B)continue to adjust the dose of insulin.After treated for 3 months,blood glucose level,body mess index (BMI),insulin dose and incidence of hypoglycemia were compared. Results The fasting blood glucose,postprandial two hours blood glucose and HbA1c between two groups was obviously decreased respectively compared with their pre-treatment (P<0.05).Group A decreased more significantly (P<0.05).There was significant difference in BMI and insulin dose before and after treatment in group A(P<0.05).The incidence of hypoglycemia was 6.7%.On the contrary,there were significant increase in BMI and insulin dose after treated in group B (P<0.05).The incidence of hypoglycemia was 16.7%. Conclusion For ineffective controlled obese type 2 diabetes patients were single treated by pre mixed insulin, plus glimepiride can effectively reduce blood glucose with lower incidence of hypoglycemia and the dose of insulin, maximum effect on BMI.